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TranscriptomicsRapid reprogramming of primary human astrocytes into potent tumor initiating cells with defined genetic factors
Cancer stem cells play key roles in human malignancies. However, their cellular and molecular origins are still poorly understood. Here we report the successful generation of cancer stem cells from primary human astrocytes by use of defined genetic factors. Combined transduction of four factors —m...
ORGANISM(S): Homo sapiens 
2016-11-07 | E-MTAB-4771 | biostudies-arrayexpress
UnknownRandomized phase III trial of induction chemotherapy with docetaxel, cisplatin, and fluorouracil followed by surgery versus up-front surgery in locally advanced resectable oral squamous cell carcinoma.
Not available
S-EPMC5569675 | biostudies-literature
Unknown[Maintenance therapy following CD19 CAR-T treatment for relapsed B-cell acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation].
Not available
S-EPMC7378295 | biostudies-literature
UnknownAnti-EGFR therapy in metastatic colorectal cancer: mechanisms and potential regimens of drug resistance.
Not available
S-EPMC7333932 | biostudies-literature
UnknownEfficient wide-bandgap perovskite photovoltaics with homogeneous halogen-phase distribution.
Not available
S-EPMC11480447 | biostudies-literature
UnknownSynthetic antimicrobial agents inhibit aflatoxin production.
Not available
S-EPMC8105457 | biostudies-literature
ProteomicsRegulation of Cortical Neurogenesis by MED13L via Transcriptional Priming and its Implications for MED13L Syndrome
MED13L is highly susceptible to neurodevelopmental disorders, yet the underlying developmental mechanisms remain poorly understood. We developed a gene knockout mouse model of MED13L syndrome to elucidate these mechanisms. Homozygous Med13l-null mice exhibit neonatal lethality and severe cortical ne...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-09 | PXD055844 | Pride
Mediator complex Neural progenitors Med13l syndrome Neurogenesis Cerebral cortex 
ProteomicsRegulation of Cortical Neurogenesis by MED13L via Transcriptional Priming and its Implications for MED13L Syndrome
MED13L is highly susceptible to neurodevelopmental disorders, yet the underlying developmental mechanisms remain poorly understood. We developed a gene knockout mouse model of MED13L syndrome to elucidate these mechanisms. Homozygous Med13l-null mice exhibit neonatal lethality and severe cortical ne...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-09 | PXD055474 | Pride
Mediator complex Neural progenitors Med13l syndrome Neurogenesis Cerebral cortex 
UnknownParental life events cause behavioral difference among offspring: Adult pre-gestational restraint stress reduces anxiety across generations.
Not available
S-EPMC5175168 | biostudies-literature
UnknownLINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway.
Not available
S-EPMC6376468 | biostudies-literature
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