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TranscriptomicsThe head-regeneration transcriptome of the planarian Schmidtea mediterranea
The head-regeneration transcriptome of the planarian Schmidtea mediterranea
ORGANISM(S): Schmidtea mediterranea 
2011-07-15 | E-MTAB-607 | biostudies-arrayexpress
Transcriptomicssingle cell RNAseq of memory B cells in the context of rituximab-treated ITP patients
Rituximab (RTX) is widely used as a first-line therapeutic strategy in B cell-mediated autoimmune diseases. However, a large proportion of patients either do not respond to the treatment or relapse during B cell reconstitution. Primary immune thrombocytopenia (ITP) is a prototypic B cell mediated au...
ORGANISM(S): Homo sapiens 
2021-01-31 | E-MTAB-9955 | biostudies-arrayexpress
TranscriptomicsSingle cell RNAseq analysis of anti-Vaccinia long-lived memory B cells (CEL-seq2)
Memory B cells represent one of the pillar of humoral protection and are found in the circulation and secondary lymphoid organs several decades after initial pathogen or vaccine encounter. The exact cellular and biological mechanisms allowing long-term survival of quiescent cells in such a fluctuati...
ORGANISM(S): Homo sapiens 
2022-09-19 | E-MTAB-11626 | biostudies-arrayexpress
TranscriptomicsCopy number Analysis of Head and Neck cancer cases from two high incidence regions
The principal objective of this work was to investigate the somatic copy number changes that influence the risk of head and neck cancer occurrence and outcome from two large comprehensive case series in Europe and South America. A second objective was to investigate how these somatic changes intera...
ORGANISM(S): Homo sapiens 
2016-06-14 | E-MTAB-4863 | biostudies-arrayexpress
TranscriptomicsStage-specific control of early B cell development by the transcription factor Ikaros
Ikaros is an essential regulator of lymphopoiesis. Here, we studied the B-cell-specific function of Ikaros by conditional Ikzf1 inactivation in pro-B cells. B-cell development was arrested at an aberrant ‘pro-B’ cell stage characterized by increased cell adhesion and loss of pre-B cell receptor sign...
ORGANISM(S): Mus musculus 
2014-02-09 | E-GEOD-53595 | biostudies-arrayexpress
TranscriptomicsATAC-seq analysis of quiescent human splenic B cell populations
Memory B cells represent one of the pillar of humoral protection and are found in the circulation and secondary lymphoid organs several decades after initial pathogen or vaccine encounter. The exact cellular and biological mechanisms allowing long-term survival of quiescent cells in such a fluctuati...
ORGANISM(S): Homo sapiens 
2022-09-19 | E-MTAB-11625 | biostudies-arrayexpress
TranscriptomicsCaste-specific RNA editomes in the leaf-cutting ant Acromyrmex echinatior
Eusocial insects have evolved the capacity to generate adults with distinct morphological, reproductive and behavioural phenotypes from the same genome. Recent studies suggest that RNA editing might enhance the diversity of gene products at the post-transcriptional level, particularly to induce func...
ORGANISM(S): Acromyrmex echinatior 
2014-10-02 | E-GEOD-51576 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of quiescent human splenic B cell populations
Memory B cells represent one of the pillar of humoral protection and are found in the circulation and secondary lymphoid organs several decades after initial pathogen or vaccine encounter. The exact cellular and biological mechanisms allowing long-term survival of quiescent cells in such a fluctuati...
ORGANISM(S): Homo sapiens 
2022-09-19 | E-MTAB-11622 | biostudies-arrayexpress
TranscriptomicsTissue-Specific Transcriptomic Insights into Myxozoan Infections: Immune and Stress Responses in the Kidney and Head Cartilage of Rainbow Trout
This experiment investigates how sequential infections with Myxobolus cerebralis and Tetracapsuloides bryosalmonae alter immune responses in rainbow trout. Using RNA-seq of kidney and head cartilage tissues, the study compares transcriptomic changes during single infections and sequential co-infecti...
ORGANISM(S): Oncorhynchus mykiss 
2026-04-25 | E-MTAB-16908 | biostudies-arrayexpress
TranscriptomicsPretreatment microRNA expression impacting on epithelial to mesenchymal transition predicts intrinsic radiosensitivity in head and neck cancer cell lines and patients [miRNA-seq]
Purpose: Predominant causes of head and neck cancer recurrence after radiotherapy are rapid repopulation, hypoxia, fraction of cancer stem cells and intrinsic radioresistance. Currently, intrinsic radioresistance can only be assessed by ex-vivo colony assays. Besides being time-consuming, colony ass...
ORGANISM(S): Homo sapiens 
2016-03-23 | E-GEOD-79493 | biostudies-arrayexpress
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