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TranscriptomicsHNSCC Cells: ctrl vs six tumour lethal miRNAs transfected
Some microRNAs have antiproliferative effects in cells and are believed to act as tumour suppressors. We used a retroviral human microRNA expression library to identify six microRNAs, miR-181a, miR-323, miR-326, miR-342, miR345 and miR-371, that induce antiproliferative effects in head and neck squa...
ORGANISM(S): Homo sapiens 
2013-11-06 | E-GEOD-34881 | biostudies-arrayexpress
TranscriptomicsmiRNA expression in head and neck squamous cell carcinoma (HNSCC)
The involvement of microRNAs (miRNAs) in cancer and their potential as biomarkers of diagnosis, prognosis and response to therapy is becoming increasingly appreciated. The etiology of head and neck squamous cell carcinoma (HNSCC) is predominantly associated with the synergistic effects of tobacco an...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-11163 | biostudies-arrayexpress
TranscriptomicsFN1 expression is a marker of radioresistance in head and neck squamous cell carcinoma
The goal of this project was to analyze differential expression in head and neck cancer cells with various intrinsic radiosensitivity. The gene expression profiles of the cell lines were determined using the Human Genome U133 plus 2.0 Arrays (Affymetrix, Santa Clara, CA). The UTSCC cells were cultur...
ORGANISM(S): Homo sapiens 
2011-06-09 | E-GEOD-21644 | biostudies-arrayexpress
ProteomicsiTRAQ-based quantitative proteomics analysis of human HNSCC cells
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer and is major cause of cancer mortality and morbidity. It emerges within oral cavity, lip, tongue, floor of the mouth, nasopharynx, palate, gingival and larynx, is common cancer worldwide especially in Southeast Asia and So...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-14 | MSV000079580 | MassIVE
TranscriptomicsRegulation of HB-EGF by miR-212 and acquired cetuximab-resistance in head and neck cancer
To determine the mechanism of cetuximab-resistance in head and neck cancer, a cetuximab-sensitive cell line (SCC1) and its cetuximab-resistant derivative (1Cc8) were analyzed for differentially expressed genes using DNA microarrays. 900 differentially expressed genes were found using the statistical...
ORGANISM(S): Homo sapiens 
2011-01-14 | E-GEOD-21483 | biostudies-arrayexpress
TranscriptomicsMolecular characterization of head and neck cancer cell model genomes
To provide full characterization of genome changes in six commonly used head and neck cancer cell lines. These data will serve as an excellent resource when designing future experiments that attempt to model HNSCC behaviour. Six commonly used ATCC head and neck cancer cell lines are analyzed.
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-16872 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiles of Head and Neck Squamous Cell Carcinoma (HNSCC) primary tumors
60 fresh frozen HNSCC from the University of North Carolina at Chapel Hill (UNC) were obtained from the UNC Tissue Procurement Facility under an IRB approved protocol. 55 tumor samples were collected from the primary tumor and five tumor samples were collected from a local recurrence at the primary ...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-686 | biostudies-arrayexpress
TranscriptomicsPretreatment microRNA expression impacting on epithelial to mesenchymal transition predicts intrinsic radiosensitivity in head and neck cancer cell lines and patients [miRNA-seq]
Purpose: Predominant causes of head and neck cancer recurrence after radiotherapy are rapid repopulation, hypoxia, fraction of cancer stem cells and intrinsic radioresistance. Currently, intrinsic radioresistance can only be assessed by ex-vivo colony assays. Besides being time-consuming, colony ass...
ORGANISM(S): Homo sapiens 
2016-03-23 | E-GEOD-79493 | biostudies-arrayexpress
TranscriptomicsIsolation and genomic characterization of cancer stem cells in head and neck cancer
This study investigated the use of three different established cell sorting strategies to isolate and characterize stem cells from head and neck cancer cell lines. Five low passage cell lines were subjected to cell sorting based on Hoechst side population, Aldefluor and CD44 expression. Isolated cel...
ORGANISM(S): Homo sapiens 
2014-03-02 | E-GEOD-55487 | biostudies-arrayexpress
ProteomicsDysregulation of splicing proteins in head and neck squamous cell carcinoma
Aberrant activation of splicing regulators contributes to oncogenic transformation of cells by modulating the alternative splicing events of key oncogenes. Phosphorylation of splicing factors affects subcellular localization and activity of these proteins. Studies have shown a close association betw...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD001862 | Pride
Head and neck squamous cell carcinoma Splicing Phosphoproteomics 
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