Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Gene Expression Profiles of Head and Neck Squamous Cell Carcinoma (HNSCC) primary tumors

ABSTRACT: 60 fresh frozen HNSCC from the University of North Carolina at Chapel Hill (UNC) were obtained from the UNC Tissue Procurement Facility under an IRB approved protocol. 55 tumor samples were collected from the primary tumor and five tumor samples were collected from a local recurrence at the primary site; one tumor also had a sample of the primary tumor and an associated lymph node metastasis . In addition, we profiled three normal tonsillar epithelium samples that were collected from three pediatric patients following routine tonsillectomy and four HNSCC tumor derived cell lines (UNC7, UMSCCA1, CAL27 and JHU022). Each experimental sample (tumor, normal or cell line) was assayed versus a â??common referenceâ?? sample that was a pool of total RNA derived from 30 of the HNSCC samples. This tumor pool reference strategy has been successfully used in another profiling study. In total, 78 experiments were performed, which utilized three separate preparations of the common reference pool. Keywords = Head and neck cancer Keywords = gene expression profiles Keywords = microarray

ORGANISM(S): Homo sapiens

SUBMITTER: Charles Perou

PROVIDER: E-GEOD-686 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression.

Chung Christine H CH Parker Joel S JS Karaca Gamze G Wu Junyuan J Funkhouser William K WK Moore Dominic D Butterfoss Dale D Xiang Dong D Zanation Adam A Yin Xiaoying X Shockley William W WW Weissler Mark C MC Dressler Lynn G LG Shores Carol G CG Yarbrough Wendell G WG Perou Charles M CM

Cancer cell 20040501 5

The prognostication of head and neck squamous cell carcinoma (HNSCC) is largely based upon the tumor size and location and the presence of lymph node metastases. Here we show that gene expression patterns from 60 HNSCC samples assayed on cDNA microarrays allowed categorization of these tumors into four distinct subtypes. These subtypes showed statistically significant differences in recurrence-free survival and included a subtype with a possible EGFR-pathway signature, a mesenchymal-enriched sub ...[more]

PMID: 15144956

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Dataset Information

Gene Expression Profiles of Head and Neck Squamous Cell Carcinoma (HNSCC) primary tumors

Publications

Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression.

Similar Datasets

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