Head and neck squamous cell carcinoma

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Unknown (6627)
Genomics (877)
Transcriptomics (618)
Clinical (122)
Proteomics (106)
Other (41)
Methylation profiling (24)
Genomic (7)
Metabolomics (7)
Multiomics (1)

Organisms

Homo sapiens (815)
Mus musculus (96)
synthetic construct (6)
Homo (4)
Rattus norvegicus (4)
Mytilus galloprovincialis (3)
Mus (3)
Schizophyllum commune (2)
Canis lupus familiaris (2)
Oncorhynchus mykiss (1)
Felis catus (1)
Human papillomavirus 16 (1)
cellular organisms (1)

Organisms

Homo sapiens (522)
Mus musculus (69)
Homo (2)
metagenome (2)
Mus (2)
Canis lupus familiaris (2)
unidentified (1)
Felis catus (1)

Repository

ENA (734)
geo (519)
biostudies-arrayexpress (248)
pride (80)
EGA (50)
MassIVE (10)
iProX (9)
dbGaP (7)
MetaboLights (7)
ExpressionAtlas (5)
jPOST (4)
PanoramaPublic (3)
EVA (2)
GPMDB (2)

Tissue

Lung (5)
Skin (5)
Blood (5)
Breast (4)
Brain (3)
Esophagus (3)
Kidney (3)
Large intestine (3)
Liver (3)
Ovary (3)
Pancreas (3)
Prostate gland (3)
Stomach (3)
Thyroid gland (3)
Urinary bladder (3)
Uterine cervix (3)
Uterus (3)
Mouth mucosa (2)
Skeletal muscle tissue (2)
Adrenal gland (1)
Bile duct (1)
Bone (1)
Connective tissue (1)
Gall bladder (1)
Hematopoietic system (1)
Mucosa (1)
Musculature (1)
Peripheral nervous system (1)
Placenta (1)
Testis (1)

Disease

Head and neck squamous cell carcinoma (36)
Cholangiocarcinoma (5)
Melanoma (5)
Bladder transitional cell carcinoma (4)
Breast adenocarcinoma (4)
Cervical squamous cell carcinoma (4)
Esophageal adenocarcinoma (4)
Follicular thyroid carcinoma (4)
Gastric adenocarcinoma (4)
Hepatocellular carcinoma (4)
Invasive lobular carcinoma (4)
Lung adenocarcinoma (4)
Ovarian adenocarcinoma (4)
Pancreatic adenocarcinoma (4)
Renal cell carcinoma (4)
Squamous cell lung carcinoma (4)
Cervical adenocarcinoma (3)
Chronic lymphocytic leukemia (3)
Colorectal adenocarcinoma (3)
Endometrial adenocarcinoma (3)
Glioblastoma multiforme (3)
Glioma (3)
Lymphoma (3)
Prostate adenocarcinoma (3)
Sarcoma (3)
Askin tumor (2)
B-cell acute lymphoblastic leukemia (2)
B-cell non-Hodgkin lymphoma (2)
Burkitts lymphoma (2)
Ewing sarcoma (2)

Technology Type

Mass Spectrometry (80)
Shotgun proteomics (43)
Bottom-up proteomics (13)
Data-dependent acquisition (10)
Affinity purification coupled with mass spectrometry proteomics (7)
Data-independent acquisition (7)
Gel-based experiment (6)
Mass spectrometry (4)
MSE (4)
Mass spectrometry assay (2)
SWATH MS (2)
454 GS FLX Titanium, Illumina HiSeq 2000 (1)
ILLUMINA, Illumina HiSeq 2000 (1)
NMR spectroscopy (1)
DiaPASEF (1)
HDMSE (1)
Mass spectrometry imaging (1)
Proteogenomics (1)
RNA mass spectrometry (1)
Top-down proteomics (1)

Instrument Platform

Illumina HiSeq 2500 (6)
Illumina NovaSeq 6000 (5)
Illumina HiSeq 2000 (3)
NextSeq 500 (3)
LTQ Orbitrap Velos (3)
Illumina HiSeq 4000 (2)
Instrument (2)
Orbitrap Fusion Lumos (2)
Gas Chromatography MS - positive (2)
DNA microarray scanner (Agilent #G2565CA) (1)
Illumina BeadArray Reader (part of Illumina BeadStation 500 (1)
Unix (1)
NextSeq 2000 (1)
Illumina MiSeq (1)
Illumina HiSeq 1500 (1)
NextSeq 550 (1)
- (1)
Illumina CanineHD (1)
LTQ Orbitrap (1)
LTQ Orbitrap Elite (1)
LTQ Orbitrap XL (1)
Q Exactive HF (1)
Q-Exactive Plus Orbitrap mass spectrometer (1)
TimsTOF Pro (1)
Autoflex speed smartbeam (1)
Liquid Chromatography MS - alternating - hilic (1)
Liquid Chromatography MS - negative - hilic (1)
Liquid Chromatography MS - negative - reverse phase (1)
Liquid Chromatography MS - positive - hilic (1)
Liquid Chromatography MS - positive - reverse phase (1)

Publication Date

2026 (95)
2025 (92)
2024 (82)
2023 (65)
2022 (62)
2014 (50)
2012 (50)
2021 (48)
2013 (47)
2016 (42)
2020 (37)
2018 (32)
2010 (32)
2011 (26)
2019 (25)
2015 (23)
2009 (22)
2017 (18)
2008 (17)
2007 (8)
2005 (5)
2006 (2)
2004 (1)

CHEBI ID

CHEBI:15428 (3)
CHEBI:15676 (3)
CHEBI:16027 (3)
CHEBI:16199 (3)
CHEBI:16335 (3)
CHEBI:17509 (3)
CHEBI:30769 (3)
CHEBI:15318 (2)
CHEBI:15603 (2)
CHEBI:15741 (2)
CHEBI:15746 (2)
CHEBI:15859 (2)
CHEBI:15891 (2)
CHEBI:15940 (2)
CHEBI:15971 (2)
CHEBI:15978 (2)
CHEBI:16000 (2)
CHEBI:16020 (2)
CHEBI:16040 (2)
CHEBI:16113 (2)
CHEBI:16119 (2)
CHEBI:16235 (2)
CHEBI:16264 (2)
CHEBI:16283 (2)
CHEBI:16344 (2)
CHEBI:16359 (2)
CHEBI:16530 (2)
CHEBI:16610 (2)
CHEBI:16695 (2)
CHEBI:16704 (2)

Metabolite Name

Creatinine (3)
Leucine (3)
Urea (3)
1-Methyladenosine (2)
3-phosphoglycerate (2)
Adenine (2)
Adenosine (2)
Alanine (2)
Cellobiose (2)
Cholic acid (2)
Creatine (2)
Glycerol (2)
Glycine (2)
Guanine (2)
Guanosine (2)
Histidine (2)
Hypoxanthine (2)
Inosine (2)
Isoleucine (2)
Kynurenic acid (2)
Lysine (2)
Nicotianamine (2)
Nicotinamide (2)
Oleamide (2)
Phenol (2)
Phenylalanine (2)
Pyrophosphate (2)
Spermidine (2)
Taurine (2)
Thymine (2)

First Public Date

2026 (114)
2025 (104)
2024 (95)
2014 (91)
2023 (69)
2022 (56)
2021 (50)
2020 (38)
2018 (35)
2019 (29)
2017 (22)
2016 (14)
2015 (11)
2013 (6)

Study status

Recruiting (42)
Completed (35)
Terminated (18)
Active, not recruiting (17)
Not provided (3)
Not yet recruiting (3)
Withdrawn (3)
Enrolling by invitation (1)

Study type

Transcription profiling by array (157)
Interventional (118)
Methylation profiling by array (27)
Comparative genomic hybridization by array (17)
RNA-seq of coding RNA (12)
MicroRNA profiling by array (5)
RNA-seq of coding RNA from single cells (4)
RNA-seq of non coding RNA (4)
Transcription profiling by SAGE (3)
Cell line - High-throughput sequencing (3)
Observational (3)
Genotyping by array (2)
MicroRNA profiling by high throughput sequencing (2)
ChIP-seq (2)
Unknown experiment type (1)
Human - Two-color microarray (1)
Human - Methylation microarray (1)
Whole chromosome random sequencing (1)
Human - One-color microarray (1)
Spatial transcriptomics by high-throughput sequencing (1)
Other (1)
DNA-seq (1)
Genotyping by high throughput sequencing (1)
Methylation profiling by high throughput sequencing (1)
Observational patient registry (1)

Release Date

2022 (858)
2023 (768)
2021 (763)
2025 (736)
2024 (706)
2020 (601)
2019 (425)
2018 (358)
2016 (303)
2017 (299)
2015 (224)
2014 (188)
2026 (122)
2013 (121)
2012 (113)
2011 (84)
2010 (77)
2009 (51)
2008 (33)
2007 (14)
2006 (13)
2005 (3)
2004 (3)
2003 (3)
2002 (3)
2001 (2)
2000 (1)
1999 (1)
1997 (1)

Lab affiliation

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland 21205 USA (4)
Department of Physiology and Biophysics, University of Illinois at Chicago (3)
Washington University in St. Louis (3)
1 Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and HUS Helsinki University Hospital, P.O.Box 263, FI-00029 HUS, Helsinki, Finland 2 Department of Biosciences and Nutrition, Karolinska Institutet, SE-171 76, Stockholm, Sweden. 3 Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland. (2)
Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands (2)
Institute of Bioinformatics , International Technology Park, Bangalore, India (2)
9McKusick-Nathans Institute of Genetic Medicine, 10Departments of Biological Chemistry, and 11Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. (1)
Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS), TUM School of Life Sciences, Technical University of Munich, Freising, Germany (1)
Bavarian Center for Biomolecular Mass Spectrometry at Klinikum rechts der Isar (BayBioMS@MRI), TUM School of Medicine and Health, Technical University of Munich (TUM), 81675 München, Germany (1)
Beijing Key Laboratory of DNA Damage Response and College of Life Science, Capital Normal University, Beijing 100048, China (1)
Biomedical Research in Cancer Stem Cells Group,Pathology Department, Collserola Building, Lab 205,Vall d'Hebron Research Institute (VHIR, Passeig Vall d'Hebron 119-129,Barcelona 08035, Spain. Tel: +34-93-489-4169 FAX: +34-93-274-6708 (1)
Biomedical Research in Cancer Stem Cells, Vall d’Hebron Research Institute (VHIR), Autonomous University of Barcelona, Passeig Vall d’Hebron 119-129, 08035 Barcelona, Spain; (1)
Biotechnology Research and Innovation Council, National Institute of Biomedical Genomics (BRIC-NIBMG), Kalyani, 741251, India. (1)
CNRS-IPHC-LSMBO (1)
Cancer Research Institute, School of Basic Medical Science, Central South University (1)
Center Leader Proteomics Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS) Technical University Munich (TUM) Gregor-Mendel-Straße 4 85354 Freising GERMANY (1)
Center for Biomedical Mass Spectrometry Boston University School of Medicine 670 Albany St, Rm 511 Boston, MA 02118-2646 USA (1)
Center for Systems Biology and Molecular Medicine Yenepoya Research Centre Yenepoya (Deemed to be University) University Road, Deralakatte Mangalore 575018, India (1)
Department Cellular and Molecular Medicine KU Leuven Belgium (1)
Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, India (1)
Department of Biochemistry, Western University, Canada (1)
Department of Biology, Technion–Israel Institute of Technology Haifa, Israel (1)
Department of Biology, University of Fribourg, Chemin du Musée 10, 1700 Fribourg, Switzerland (1)
Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China (1)
Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA (1)
Department of Medicine II, Hematology/Oncology, Goethe University, Germany German Cancer Research Center and German Cancer Consortium, Germany (1)
Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, 6525 GA, The Netherlands (1)
Department of Molecular Cell Biology The Weizmann Institute of Science Rehovot, Israel (1)
Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA. (1)
Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland (1)

Location

United States (98)
Spain (20)
France (17)
Australia (16)
United Kingdom (16)
Canada (15)
Italy (13)
Belgium (12)
Germany (11)
Netherlands (8)
South Korea (8)
Japan (7)
Taiwan (7)
Israel (6)
Austria (5)
China (5)
Denmark (4)
Poland (4)
Switzerland (4)
Argentina (3)
Czechia (3)
Singapore (3)
Asia except Japan (2)
Brazil (2)
Europe (2)
Georgia (2)
Hong Kong (2)
North America (2)
Oceania (2)
Turkey (2)

Keyword

Pembrolizumab (26)
Cetuximab (15)
Nivolumab (15)
CRC (13)
Immunotherapy (11)
HNSCC (10)
SCCHN (8)
EGFR (7)
Antibodies, Monoclonal (5)
Carboplatin (5)
Colorectal (5)
Ipilimumab (5)
Metastatic (5)
Paclitaxel (5)
PD-1 (4)
RCC (4)
Spartalizumab (4)
Squamous cell carcinoma (4)
TNBC (4)
Albumin-Bound Paclitaxel (3)
Antibodies (3)
Antineoplastic Agents, Immunological (3)
Avelumab (3)
Durvalumab (3)
EGFR Positive (3)
EGFR+ (3)
Gastroesophageal Junction Cancer (3)
Gemcitabine (3)
HER2 (3)
Head and Neck (3)

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Gene expression profiles of head and neck squamous cell carcinoma

Sage performed on microdissection of Head and Neck tumor, and Head and Neck normal tissue comparative analysis of gene expression profiles of head and neck squamous cell carcinoma and Head and Neck normal tissue

ORGANISM(S): Homo sapiens

2008-09-30 | E-GEOD-11986 | biostudies-arrayexpress

System Xc- exacerbates metabolic stress under glucose depletion in oral squamous cell carcinoma

OBJECTIVE: Emerging evidence suggests that glucose depletion (GD)-induced cell death depends on system Xc-, a glutamate/cystine antiporter extensively studied in ferroptosis. However, the underlying mechanism remains debated. Our study confirmed the correlation between system Xc...

2024-01-16 | MTBLS5358 | MetaboLights

Mechanistic study of the effects of salivary components from OSCC patients on tumor growth using a mouse model of oral squamous cell carcinoma

2025-08-01 | MTBLS12805 | MetaboLights

Transcription profiling of human head and neck paired diseased squamous cell carcinoma samples vs normal

Forty-four paired (from the same patient) samples of head and neck squamous cell carcinoma (HNSCC) and normal tissue were studied with Affymetrix U95A chips. A stringent multi-test approach, combining 7 traditional and microarray-specific statistical tests, was used to analyze the resultant data. Ca...

ORGANISM(S): Homo sapiens

2009-02-06 | E-GEOD-6631 | biostudies-arrayexpress

MethylationEPIC array from fresh oral and oropharyngeal tissue samples from head and neck squamous cell carcinoma patients, tissue samples from potentially premalignant oral lesions and fresh tonsil tissue samples from control patients

This data was used to detect good biomarkers for head and neck squamous cell carcinoma and was integrated with transcriptome and miRNome data aiming to elucidate role of epigenetics on gene expression in head and neck squamous cell carcinoma.

ORGANISM(S): Homo sapiens

2024-04-22 | E-MTAB-13954 | biostudies-arrayexpress

miRNA expression in head and neck squamous cell carcinoma (HNSCC)

The involvement of microRNAs (miRNAs) in cancer and their potential as biomarkers of diagnosis, prognosis and response to therapy is becoming increasingly appreciated. The etiology of head and neck squamous cell carcinoma (HNSCC) is predominantly associated with the synergistic effects of tobacco an...

ORGANISM(S): Homo sapiens

2010-05-19 | E-GEOD-11163 | biostudies-arrayexpress

iTRAQ-based quantitative proteomics analysis of human HNSCC cells

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer and is major cause of cancer mortality and morbidity. It emerges within oral cavity, lip, tongue, floor of the mouth, nasopharynx, palate, gingival and larynx, is common cancer worldwide especially in Southeast Asia and So...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2016-03-14 | MSV000079580 | MassIVE

Insulin-like growth factor-1 receptor inhibitor, AMG-479, in cetuximab-refractory head and neck squamous cell carcinoma

Recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) remains one of the most difficult cancers to treat with limited chemotherapeutic options. Here, we describe a patient with HNSCC who had complete response to methotrexate (MTX) after progressing on multiple cytotoxic agents; c...

ORGANISM(S): Homo sapiens

2010-08-03 | E-GEOD-9600 | biostudies-arrayexpress

FN1 expression is a marker of radioresistance in head and neck squamous cell carcinoma

The goal of this project was to analyze differential expression in head and neck cancer cells with various intrinsic radiosensitivity. The gene expression profiles of the cell lines were determined using the Human Genome U133 plus 2.0 Arrays (Affymetrix, Santa Clara, CA). The UTSCC cells were cultur...

ORGANISM(S): Homo sapiens

2011-06-09 | E-GEOD-21644 | biostudies-arrayexpress

Dysregulation of splicing proteins in head and neck squamous cell carcinoma

Aberrant activation of splicing regulators contributes to oncogenic transformation of cells by modulating the alternative splicing events of key oncogenes. Phosphorylation of splicing factors affects subcellular localization and activity of these proteins. Studies have shown a close association betw...

ORGANISM(S): Homo sapiens (Human)

2018-10-24 | PXD001862 | Pride

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OBJECTIVE: Emerging evidence suggests that glucose depletion (GD)-induced cell death depends on system Xc-, a glutamate/cystine antiporter extensively studied in ferroptosis. However, the underlying mechanism remains debated. Our study confirmed the correlation between system Xc...

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