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MetabolomicsUntargeted gas chromatography–mass spectrometry-based metabolomics analysis of kidney and liver tissue from the Lewis Polycystic Kidney rat
Polycystic kidney disease (PKD) encompasses a spectrum of inherited disorders that lead to end-stage renal disease (ESRD). There is no cure for PKD and current treatment options are limited to renal replacement therapy and transplantation. A better understanding of the pathobiology of PKD is needed ...
2023-01-26 | MTBLS748 | MetaboLights
MetabolomicsGlobal analysis of plasma lipidomics reveals altered lipid signatures in patients with osteonecrosis of the femoral head

AIMS: Although studies have made the connection between lipid metabolism disorder and osteonecrosis of the femoral head (ONFH), the characteristics of the circulating lipidome signature of ONFH have not yet been investigated yet and need to be explored.

METHODS:

2021-07-06 | MTBLS2262 | MetaboLights
TranscriptomicsInflammatory response of trout head kidney to in vivo challenge with IHN virus and LPS
The response of the trout, O.mykiss, head kidney to bacterial lipopolysaccharide (LPS) or active and attenuated infectious hematopoietic necrosis virus (IHNV and attINHV respectively) intraperoniteal challenge, 24 and 72 hours post-injection, was investigated using a salmonid-specific cDNA microarra...
ORGANISM(S): Oncorhynchus mykiss 
2010-06-25 | E-GEOD-10272 | biostudies-arrayexpress
ProteomicsMetabolic, Neurotoxic and Immunotoxic Effects of PFAAs and their Mixtures on the Proteome of Plasma and Head Kidney from Rainbow Trout
PFAAs (Perfluoroalkyl acids) are a class of bioaccumulative, persistent and ubiquitous aquatic contaminants. A paucity of toxicological information exists for short chain PFAAs and PFAA mixtures. In order to address these knowledge gaps, we performed a 3-week, aqueous exposure of rainbow trout to 3 ...
ORGANISM(S): Oncorhynchus Mykiss 
PXD046517 | panorama
TranscriptomicsTranscription profiling by array of Atlantic salmon head kidney cells infected with infectious pancreatic necrosis virus
Infectious pancreatic necrosis (IPN) is a serious viral disease that causes significant economic losses in salmon aquaculture. To characterize the host-pathogen relationship in IPN, we analysed transcriptional profiles of salmon head kidney (SHK-1) cells infected with infectious pancreatic necrosi...
ORGANISM(S): Salmo salar 
2011-01-01 | E-TABM-1000 | biostudies-arrayexpress
ProteomicsShotgun proteomic profiling of head kidney of rainbow trout Oncorhynchus mykiss
The objective of this study was to identify and quantify proteomic profiles of head kidney of rainbow trout Oncorhynchus mykiss. Specific pathogen free rainbow trout (mean length 15 ± 1 cm) were maintained in recirculating de-chlorinated water at 19±1 °C. Prior to the experiment, fish were distribut...
ORGANISM(S): Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 
2018-08-14 | PXD008473 | Pride
Lc ms-ms Head kidney Rainbow trout Proteome profile 
TranscriptomicsGene expression profile after oral vaccination against infectious pancreatic necrosis virus (IPNV)
Oral immunization of trout against infectious pancreatic necrosis virus (IPNV) have been recently reported by using a DNA vector coding the viral capsid VP2 gene encapsulated in alginate microspheres. We report here an study of the transcripts in head kidney and pyloric ceca 7 days after oral vaccin...
ORGANISM(S): Oncorhynchus mykiss 
2012-07-18 | E-GEOD-31591 | biostudies-arrayexpress
TranscriptomicsTissue-Specific Transcriptomic Insights into Myxozoan Infections: Immune and Stress Responses in the Kidney and Head Cartilage of Rainbow Trout
This experiment investigates how sequential infections with Myxobolus cerebralis and Tetracapsuloides bryosalmonae alter immune responses in rainbow trout. Using RNA-seq of kidney and head cartilage tissues, the study compares transcriptomic changes during single infections and sequential co-infecti...
ORGANISM(S): Oncorhynchus mykiss 
2026-04-25 | E-MTAB-16908 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of spleen, liver and head kidney in turbot (Scophthalmus maximus) along the infection process with Philasterides dicentrarchi using an immune-enriched oligo-microarray
We evaluated the expression profiles of turbot in spleen, liver and head kidney across five temporal points of the Philasterides dicentrarchi infection process using an 8x15K Agilent oligo-microarray. The microarray included 2,176 different 5-fold replicated gene probes designed from a turbot 3’ seq...
ORGANISM(S): Scophthalmus maximus 
2012-01-24 | E-GEOD-35184 | biostudies-arrayexpress
TranscriptomicsAquafirst_seabream_pathogen exposure_head kidney
To determine the effects of pathogen exposure to Enteromyxum leei on head kidney gene expression. Keywords: confinement, cortisol, stress response, time course, microarray 30 head kidney samples - Thirty slides were hybridised using a reference design. Three groups (control, infected and non-infect...
ORGANISM(S): Sparus aurata 
2010-02-28 | E-GEOD-18219 | biostudies-arrayexpress
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