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MetabolomicsMetabolomics of heart tissue at baseline and following myocardial infarction
A comprehensive analysis of the heart metabolome was conducted at 60 min reperfusion post ischaemia. This analysis employed LC-MS/MS in order to provide a detailed examination of the metabolic processes occurring within the heart. The focus of this analysis was placed on glycolysis, the tricarboxyli...
2026-04-30 | MTBLS14417 | MetaboLights
MetabolomicsSequential lipidomic, metabolomic, and proteomic analyses of serum, liver, and heart tissue specimens from peroxisomal biogenesis factor 11α knockout mice
Peroxisomes are versatile single membrane-enclosed cytoplasmic organelles, involved in reactive oxygen species (ROS) and lipid metabolism and diverse other metabolic processes. Peroxisomal disorders result from mutations in Pex genes-encoded proteins named peroxins (PEX proteins) and single peroxiso...
2022-02-02 | MTBLS1887 | MetaboLights
MetabolomicsButyrate ameliorate doxorubicin-induced heart failure via microbiota/ metabolites-gut-Heart axis
Doxorubicin(DOX) is widely used in cancer chemotherapy with a limitation of DOX-induced cardiotoxicity(DIC),resulting in heart failure(HF).HF accompanies by gut microbial dysbiosis.However,how gut microbiota regulate DIC-induced heart failure (DIHF)remains unclear.Here, we established a susceptibili...
2025-09-13 | MTBLS11830 | MetaboLights
MetabolomicsCross-modal Integration of Metabolomics and Cardiac Functionality Captures Dynamic Metabotoxic Effects of Doxorubicin in Engineered Heart Tissues

Functional stem cell-derived heart models offer new avenues for preclinical, animal-free physiological assessment of drug cardiotoxicity. Yet, comprehensive molecular profiling in these models remains limited, leaving key metabolic drivers of cardiotoxicity unexplored.

Here, we leveraged an...

2025-12-07 | MTBLS13225 | MetaboLights
MetabolomicsMRG15 orchestrates glycolysis and the pentose phosphate pathway to facilitate heart regeneration following myocardial infarction
Metabolic reprogramming is crucial for adult heart regeneration after myocardial infarction (MI). Here, we identify the MORF4-related gene on chromosome 15 (MRG15) as a key orchestrator of cardiomyocyte metabolism to drive cardiomyocyte proliferation. MRG15 expression is upregulated in both hypoxic ...
2026-09-22 | MTBLS15770 | MetaboLights
MetabolomicsMRG15 orchestrates glycolysis and the pentose phosphate pathway to facilitate heart regeneration following myocardial infarction
Metabolic reprogramming is crucial for adult heart regeneration after myocardial infarction (MI). Here, we identify the MORF4-related gene on chromosome 15 (MRG15) as a key orchestrator of cardiomyocyte metabolism to drive cardiomyocyte proliferation. MRG15 expression is upregulated in both hypoxic ...
2026-09-22 | MTBLS15769 | MetaboLights
MetabolomicsButyrate ameliorate doxorubicin-induced heart failure via microbiota/ metabolites-gut-Heart axis
Doxorubicin(DOX) is widely used in cancer chemotherapy with a limitation of DOX-induced cardiotoxicity(DIC),resulting in heart failure(HF).HF accompanies by gut microbial dysbiosis.However,how gut microbiota regulate DIC-induced heart failure (DIHF)remains unclear.Here, we established a susceptibili...
2025-09-12 | MTBLS11819 | MetaboLights
MetabolomicsGRSF1 Protects Against Heart Failure by Maintaining BCAA Homeostasis

BACKGROUND: Imbalances in cardiac branched-chain amino acid (BCAA) metabolism and mitochondrial homeostasis are implicated in the onset and development of heart failure. However, the mechanisms triggering the downregulation of cardiac BCAA metabolism in heart failure remain unclear. Here, we iden...

2025-10-19 | MTBLS13178 | MetaboLights
MetabolomicsA Combined Metabolomic and Proteomic Investigation of the Effects of a Failure to Express Dystrophin in the Mouse Heart
Muscle degeneration in the heart of 1-9 month-old mdx mice (a model for Duchenne muscular dystrophy) has been monitored using metabolomic and proteomic approaches. In both data sets, a pronounced aging trend was detected in control and mdx mice, and this trend was separate from the disease process. ...
2017-03-14 | MTBLS256 | MetaboLights
MetabolomicsMetabolomic profiling of mouse heart in a model of Cardiovascular-Kidney-Metabolic syndrome

Cardiovascular-kidney-metabolic (CKM) syndrome is a complex systemic disorder. In this study, we developed a urea-activated nanoparticle (T-PAAD NP) for targeted delivery of Empagliflozin to the renal S1 segment. Untargeted GC-MS-based metabolomics was performed to characterize metabolic reprogra...

2026-03-21 | MTBLS13991 | MetaboLights
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