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MetabolomicsSS-31 and NMN: Two Paths to Improve Metabolism and Function in Aged Hearts
Not available
ORGANISM(S): Mus musculus 
ST001329 | MetabolomicsWorkbench
MetabolomicsUntargeted metabolomics analysis of ischemia-reperfusion injured hearts ex vivo from sedentary and exercise trained rats.
Not available
ORGANISM(S): Rattus norvegicus 
ST000897 | MetabolomicsWorkbench
TranscriptomicsMitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin; germline Parkin knockout mouse hearts.
Dysfunctional Parkin-mediated mitophagic culling of senescent or damaged mitochondria is a major pathological process underlying Parkinson disease and a potential genetic mechanism of cardiomyopathy. Despite epidemiological associations between Parkinson disease and heart failure, the role of Parkin...
ORGANISM(S): Mus musculus 
2015-10-31 | E-GEOD-74517 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse hearts from mutants lacking estrogen-related receptor alpha (ERRalpha), a nuclear receptor
Total RNA was isolated from 3 WT and 3 ERRalpha null hearts and independent hybridizations were performed using MOE430 2.0 microarrays. Expression profiling was conducted to determine changes in gene expression in hearts lacking ERRa. The expression of genes involved in heart and muscle development,...
ORGANISM(S): Mus musculus 
2007-11-10 | E-GEOD-7196 | biostudies-arrayexpress
TranscriptomicssnRNA-seq of whole hearts from adult BL6 mice
We used snRNA-seq to investigate an entire adult mammalian heart of BL6 mice. Whole hearts were harvested from 4 male mice (12 weeks) after cervical dislocation. The hearts were pooled and nuclei isolated using the Nuclei PURE Prep isolation kit (Sigma-Aldrich, Darmstadt, Germany) according to the m...
ORGANISM(S): Mus musculus 
2020-03-16 | E-MTAB-8848 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse caveolin-3 knockout hearts
Energy Substrate Uptake and Metabolism are Preserved in Hypertrophic Caveolin-3 Knockout Hearts Experiment Overall Design: 3 wild types, 3 knockouts
ORGANISM(S): Mus musculus 
2009-03-15 | E-GEOD-10848 | biostudies-arrayexpress
TranscriptomicssnRNA-seq of whole hearts from adult fzt:DU mice
We used snRNA-seq to investigate for the first time an entire adult mammalian heart. To avoid potential aberrations due to inbreeding, we relied on an outbred mice strain (Fzt:DU) (Dietl, G.; Langhammer, M.; Renne, U. Model simulations for genetic random drift in the outbred strain Fzt:DU. Arch. Ani...
ORGANISM(S): Mus musculus 
2020-02-22 | E-MTAB-8751 | biostudies-arrayexpress
TranscriptomicsAnalysis of Ppif-/- hearts
To identify differences in gene expression between peptidylprolyl isomerase F (cyclophilin D; Ppif)-null hearts and WT control hearts. RNA was isolated from mice 8 weeks of age to discover gene changes prior to myocardial dysfunction. Three replicates each of Ppif-/- and WT mice.
ORGANISM(S): Mus musculus 
2011-01-05 | E-GEOD-23028 | biostudies-arrayexpress
TranscriptomicsMolecular classification of failing hearts from coronary and myopathic patients
RNA form the heart a goupe of 9 patients with end stage cardiomyopathy (CAD) and 11 patiensts with coronary artery disease (CAD) was hybridized against pooled RNA form 4 normal nonfailing hearts.
ORGANISM(S): Homo sapiens 
2010-06-06 | E-GEOD-2014 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Wistar rat preconditioned hearts either perfused alone or subjected to ischemia and then reperfused
Isolated perfused rat hearts exposed to isoflurane or ischemic preconditioning, a subgroup followed by 40 minutes of ischemia and 3 hours of reperfusion. Exact protocol available from the authors.
ORGANISM(S): Rattus norvegicus 
2007-11-01 | E-GEOD-1616 | biostudies-arrayexpress
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