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MetabolomicsDecoding heat-shock responses in Vitis vinifera L. by metabolic, VOC and physiological profiling: towards the identification of volatile and metabolic biomarkers

Grapevine (Vitis spp.) is a crop of major economic importance in Europe. Rising temperatures and extreme weather events reduce yield and alter berry composition, affecting wine quality. Despite advances in vineyard management, mechanisms underlying grapevine thermotolerance remain poorly understo...

2026-06-26 | MTBLS13195 | MetaboLights
MetabolomicsAcute heat stress amplifies exercise-induced metabolomic perturbations and reveals variation in circulating amino acids in endurance-trained males

Using untargeted metabolomics, we aimed to characterise the systemic impact of environmental heat stress during exercise. Twenty-three trained male triathletes completed a 30-min exercise test in hot (35°C) and temperate (21°C) conditions. Venous blood samples were collected immediately pre- and ...

2025-08-14 | MTBLS6051 | MetaboLights
MetabolomicsGut Microbiota Contributes to Heat Tolerance Through Metabolic Remodeling and Suppression of Thermogenesis in Chickens
Background The gut microbiota is increasingly recognized as a key regulator of host metabolic adaptation to environmental challenges. However, whether breed-specific gut microbiota contributes to variation in heat tolerance among poultry breeds remains unclear. This study used Cyan-shank partridge c...
2026-06-18 | MTBLS14785 | MetaboLights
MetabolomicsUntargeted serum metabolomics of dairy goats under heat stress and melatonin supplementation
Serum untargeted metabolomic profiling was performed to characterize metabolic alterations induced by heat stress and to evaluate the potential protective effects of melatonin supplementation in dairy goats. Serum samples were collected from dairy goats assigned to three experimental groups: a norma...
2026-09-10 | MTBLS15437 | MetaboLights
MetabolomicsProbiotics alleviated heat stress-induced spermatogenesis dysfunction by remodeling gut microbiota and producing arginine and pantothenic acid

BACKGROUND: Large-scale farms struggle to effectively address summer heat stress (HS) in dairy goats, which impairs spermatogenesis and reduces reproductive performance by compromising gut and reproductive organ health in male animals. Although Clostridium butyricum (CB) and Enterococcus faecium ...

2025-07-31 | MTBLS12573 | MetaboLights
MetabolomicsMetabolic responses of rice cultivars with different tolerance to combined heat and drought stress under field conditions
Rice is susceptible to both heat and drought stress, in particular during flowering and grain filling, when both grain yield and quality may be severely compromised. However, under field conditions, these two stresses rarely occur separately. Under well-watered conditions, plants avoid heat stress b...
2019-04-25 | MTBLS801 | MetaboLights
MetabolomicsA multi-omics approach to unravel the interaction between heat and drought stress in the Arabidopsis thaliana holobiont
The impact of combined heat and drought stress was investigated in Arabidopsis thaliana and compared to individual stresses to reveal additive effects and interactions. A combination of plant metabolomics and root and rhizosphere bacterial metabarcoding were used to unravel effects at the plant holo...
2024-12-16 | MTBLS7365 | MetaboLights
MetabolomicsCharacterization of the heat-stable proteome during seed germination in Arabidopsis with special focus on LEA proteins
During seed germination, desiccation tolerance is lost in the radicle with progressing radicle protrusion and seedling establishment. This process is accompanied by comprehensive changes of the metabolome and proteome. Germination of Arabidopsis seeds was investigated over 72 h with special focus on...
2021-07-29 | MTBLS2980 | MetaboLights
MetabolomicsHeat drives tomato bacterial wilt through enhanced pathogen virulence and rhizosphere microbiome and metabolic shifts
Bacterial wilt caused by Ralstonia solanacearum is globally widespread and strongly associated with elevated temperature, yet the ecological mechanisms underlying temperature-driven disease outbreaks remains unclear. Here, we show that high temperature promotes bacterial wilt by reconfiguring the to...
2026-05-31 | MTBLS14437 | MetaboLights
MetabolomicsIntegrated Multi-Omics Analysis of Dampness-Heat Gout Reveals Diagnostic Biomarkers and Therapeutic Targets

Damp-heat gout (DHG) is a clinically recognized subtype of gout characterized by a specific syndrome in traditional Chinese medicine (TCM). However, its pathomechanism remains unclear, and there is a lack of quantifiable indicators for accurate clinical diagnosis and treatment. This study aimed t...

2026-02-04 | MTBLS12820 | MetaboLights
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