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ProteomicsA standardized and reproducible workflow for membrane glass slides in routine histology and spatial proteomics
Defining the molecular phenotype of single cells in-situ is essential for understanding tissue heterogeneity in health and disease. Powerful imaging technologies have recently been joined by spatial omics technologies, promising unparalleled insights into the molecular landscape of biological sample...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD040281 | Pride
Antigen retrieval Spatial proteomics Deep visual proteomics Glycerol Membrane slides Histology Proteomics Heat-induced epitope retrieval Laser microdissection 
UnknownEnhanced detection of distinct honeycomb-structured neuronal SMARCC2 cytobodies in Parkinson's Disease via Cyclic Heat-Induced Epitope Retrieval (CHIER).
Not available
S-EPMC11651576 | biostudies-literature
UnknownEffect of Antigen Retrieval on Genomic DNA From Immunodissected Samples.
Not available
S-EPMC9527476 | biostudies-literature
ProteomicsSpatially variant immune infiltration scoring in human cancer tissues
The Immunoscore is a method to quantify the immune cell infiltration within cancers to predict the disease prognosis. Previous immune profiling approaches relied on limited immune markers to establish patients’ tumor immunity. However, immune cells exhibit a higher-level complexity that is typically...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD035340 | Pride
Lung cancer imc 
UnknownA Standardized and Reproducible Workflow for Membrane Glass Slides in Routine Histology and Spatial Proteomics.
Not available
S-EPMC10565769 | biostudies-literature
UnknownExtracellular Vesicle Antibody Microarray for Multiplexed Inner and Outer Protein Analysis.
Not available
S-EPMC9791990 | biostudies-literature
UnknownImmunohistochemical Detection of Estrogen Receptor-Beta (ERβ) with PPZ0506 Antibody in Murine Tissue: From Pitfalls to Optimization.
Not available
S-EPMC9775465 | biostudies-literature
OtherFull-length target sequences of GeoMx Digital Spatial Profiling probes reveal that gene-promiscuity predicts probe sensitivity to EDTA tissue decalcification
GeoMx Digital Spatial Profiling (Nanostring) is a commercial spatial transcriptomics method to selectively analyze regions of interest within intact tissue sections. However, it is unclear how tissue decalcification affects the results of this assay, or if decalicified samples are comparable to untr...
ORGANISM(S): Homo sapiens 
2024-09-18 | GSE272995 | GEO
ProteomicsIntegrative Spatial Proteomics and Single-Cell RNA Sequencing Unveil Molecular Complexity in Rheumatoid Arthritis for Novel Therapeutic Targeting
Understanding the heterogeneity of Rheumatoid Arthritis (RA) and identifying therapeutic targets remain challenging using traditional bulk transcriptomics alone, as it lacks the spatial and protein-level resolution needed to fully capture disease and tissue complexities. In this study, we applied La...
ORGANISM(S): Homo sapiens (Human) 
2025-06-26 | PXD062696 | Pride
Human Laser capture microdissection Synovium membrane Lc-ms/ms 
GenomicsThor: a platform for cell-level investigation of spatial transcriptomics and histology [Bladder Cancer]
Thor: a platform for cell-level investigation of spatial transcriptomics and histology [Bladder Cancer]
PRJNA1281678 | ENA
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