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ProteomicsStructural insights into a HECT-type E3 ligase AREL1
Structural insights into a HECT-type E3 ligase AREL1 and its ubiquitination activities in vitro
ORGANISM(S): Homo sapiens (Human) 
2019-11-25 | PXD016016 | Pride
Second mitochondria-derived activator of caspase (smac) Cancer Hect domain Apoptosis-resistant e3 ligase 1 (arel1) Structural biology Autopolyubiquitination Ubiquitination Protein degradation Apoptosis Posttranslational modification 
UnknownRegulating the human HECT E3 ligases.
Not available
S-EPMC6063350 | biostudies-literature
UnknownRedefining the catalytic HECT domain boundaries for the HECT E3 ubiquitin ligase family.
Not available
S-EPMC9547173 | biostudies-literature
ProteomicsTherapeutic potential of allosteric HECT E3 ligase inhibition
Supplemental proteomics data Abstract: Inhibition of ubiquitin E3-ligases is therapeutically attractive; however, the absence of an active-site pocket impedes computational approaches to inhibitor identification. In a large unbiased physical screen, we discovered inhibitors that bind a cryptic cavi...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD051134 | Pride
Drug discovery E6ap Pulmonary arterial hypertension Small molecule Ubiquitin e3-ligase Vascular remodeling Hect Allosteric inhibition Smurf1 Glycine hinge 
ProteomicsHECTD3 is a small HECT E3 ligase with unique features
HECT E3 ligases regulate many cellular processes, yet how they recognise their substrates and synthesise specific types of poly-ubiquitin chains is still incompletely understood. HECTD3, a member of the “other HECT” family, is implicated in the regulation of inflammation, apoptosis, and infection an...
ORGANISM(S): Homo sapiens (Human) 
2026-01-15 | PXD066996 | Pride
E3 ligase Cross-linking 
UnknownUbFluor: A Mechanism-Based Probe for HECT E3 Ligases.
Not available
S-EPMC4965700 | biostudies-literature
UnknownHECT E3 Ligases: A Tale With Multiple Facets.
Not available
S-EPMC6457168 | biostudies-literature
UnknownProtein semisynthesis reveals plasticity in HECT E3 ubiquitin ligase mechanisms.
Not available
S-EPMC12087361 | biostudies-literature
UnknownGenome-wide analysis of HECT E3 ubiquitin ligase gene family in Solanum lycopersicum.
Not available
S-EPMC8342558 | biostudies-literature
UnknownEmerging roles of the HECT-type E3 ubiquitin ligases in hematological malignancies.
Not available
S-EPMC8777521 | biostudies-literature
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