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TranscriptomicsMolecular basis for chromatin binding and regulation of MLL5
The human mixed lineage leukemia 5 (MLL5) protein mediates hematopoietic cell homeostasis, cell cycle and survival, however, the molecular basis underlying MLL5 activities remains unknown. Here, we show that MLL5 is recruited to gene-rich euchromatic regions via the interaction of its PHD finger wit...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-47100 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of B7.5 lineage cells in the tunicate Ciona intestinalis to study cardiac cell migration
Eight different types of sample (three samples each) were used in this study of cardiac cell migration in the tunicate Ciona intestinalis. The B7.5 lineage cells were isolated by Fluorescent Activated Cell Sorting (FACS) at the tailbud stage, when the cardiac precursors (anterior B7.5 lineage cells)...
ORGANISM(S): Ciona intestinalis 
2008-06-01 | E-MEXP-1478 | biostudies-arrayexpress
Genomics1,25-Dihydroxyvitamin D3 Controls a Cohort of Vitamin D Receptor Target Genes in the Proximal Intestine That Is Enriched for Calcium Regulating Components (ChIP-seq)
1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) plays an integral role in calcium homeostasis in higher organisms through its actions in the intestine, kidney and skeleton. Interestingly, while several intestinal genes are known to play a contributory role in calcium homeostasis, the entire caste of key comp...
ORGANISM(S): Mus musculus 
2015-06-03 | E-GEOD-69179 | biostudies-arrayexpress
TranscriptomicsComparison of the in vivo transcriptome of the myometrium to the transcriptome of myometrial explants, primary cultured myometrial cells and the hTert myometrial cell line
Circulating progesterone (P4) levels decline before the onset of parturition in most animals, but not in humans. This has led to the suggestion that there is functional withdrawal of P4 action at the myometrial level prior to labor onset. Mifepristone is widely used to induce human labour In this st...
ORGANISM(S): Homo sapiens 
2016-05-30 | E-GEOD-77830 | biostudies-arrayexpress
ProteomicsEffects of the chlorophyll derivative 132-hydroxypheophytine a on zebrafish metabolomics
Zebrafish larvae were exposed from 3 DPF to 5 DPF to the chlorophyll derivative 13-2-hydroxypheophytine a. Metabolites were extracted with some modification of the protocol published by Lin et al 2019 (10.1016/j.bbrc.2019.04.003.). 3 experimental groups: DMSO 0.1% (solvent control) and hpa at 7.5 ug...
ORGANISM(S): Danio Rerio (ncbitaxon:7955) 
2023-06-16 | MSV000092187 | MassIVE
Transcriptomics1,25-Dihydroxyvitamin D3 Controls a Cohort of Vitamin D Receptor Target Genes in the Proximal Intestine That Is Enriched for Calcium Regulating Components (RNA-seq)
1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) plays an integral role in calcium homeostasis in higher organisms through its actions in the intestine, kidney and skeleton. Interestingly, while several intestinal genes are known to play a contributory role in calcium homeostasis, the entire caste of key comp...
ORGANISM(S): Mus musculus 
2015-06-03 | E-GEOD-69170 | biostudies-arrayexpress
UnknownPrediction of primary non-response to methotrexate therapy using demographic, clinical and psychosocial variables: results from the UK Rheumatoid Arthritis Medication Study (RAMS).
Not available
S-EPMC6044018 | biostudies-literature
UnknownECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells
Not available
S-SCDT-EMBOJ-2021-109205 | biostudies-other
TranscriptomicsTumor exosome integrins determine organotropic metastasis
Stephen Paget first proposed, in 1889, that organ distribution of metastases is a non-random event, yet metastatic organotropism remains one of the greatest mysteries in cancer biology. Here, we demonstrate that exosomes released by lung-, liver- and brain-tropic tumor cells fuse preferentially with...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-68919 | biostudies-arrayexpress
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