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TranscriptomicsExpression data from fine-needle aspiration biopsies of breast cancer metastases from different anatomical sites
Breast cancer molecular subtypes preferentially metastasize to specific organs and the anatomical location of the metastasis is associated with the length of survival post-recurrence. We used microarrays to provide a detailed characterization of breast cancer site-specific metastases with particula...
ORGANISM(S): Homo sapiens 
2013-12-02 | E-GEOD-46141 | biostudies-arrayexpress
TranscriptomicsOvercoming chemoresistance in B lymphoma cells: elucidating the role of NF-kB in caspase-independent apoptosis by transcriptomic assessment.
Although therapy responsiveness to therapy in Burkitt lymphoma (BL) is high, relapsed disease and and chemoresistance remain a clinical challenge, and complete mechanisms underlying BL chemoresistance and how it can be circumvented is yet to be fully elucidated. In this study we present data showing...
ORGANISM(S): Homo sapiens 
2014-01-19 | E-GEOD-31258 | biostudies-arrayexpress
TranscriptomicsCo-targeting of the PI3K pathway improves the response of BRCA1 deficient breast cancer cells to PARP1 inhibition
Although pre-clinical and clinical studies on PARP1 inhibitors, alone and in combination with DNA-damaging agents, show promising results, further ways to improve and broaden the scope of application of this therapeutic approach are warranted. To this end, we have investigated the possibility of imp...
ORGANISM(S): Homo sapiens 
2012-01-19 | E-GEOD-34817 | biostudies-arrayexpress
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