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ProteomicsThe Drosophila Epidermal growth factor receptor pathway regulates Hedgehog signalling and cytoneme behaviour.
During Drosophila epithelial development, dynamic signalling filopodia (cytonemes) establish direct contacts between distant cells to facilitate the formation of the Hedgehog signalling gradient. However, not much is known about how cytonemes are regulated. In this study, we show that cytoneme dynam...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-05-06 | PXD040793 | Pride
Ihog Development. Hedgehog signalling Egfr Cytonemes 
TranscriptomicsEctopic Hedgehog signalling causes cleft palate and defective osteogenesis
In this study, we have investigated the molecular basis of Shh signalling during development of the secondary palate and how CNCC patterning and fate is influenced by the Shh signalling network. Using a gain-of-function mouse model to activate Smoothened (R26SmoM2) signalling in the palatal mesenchy...
ORGANISM(S): Mus musculus 
2018-10-02 | E-MTAB-5518 | biostudies-arrayexpress
TranscriptomicsExpression data from colon fibroblasts treated with Sonic hedgehog homolog (SHH)
Canonical Hedgehog (Hh) signaling regulates the expression of genes that are critical to the patterning and development of a variety of organ systems. In adult, both ligand-dependent and ligand-independent Hh pathway activation are known to promote tumorigenesis. Recent studies have shown that in tu...
ORGANISM(S): Homo sapiens 
2011-05-17 | E-GEOD-29316 | biostudies-arrayexpress
TranscriptomicsHistone deacetylase 6 exerts dichotomous effects on the Hedgehog signaling cascade
Murine embryo fibrablosts from stably transfected with Sonic Hedgehog were treated with siRNA and their transcription profiles captured.
ORGANISM(S): Mus_musculus 
2015-01-26 | E-MTAB-2440 | biostudies-arrayexpress
TranscriptomicsEVC protein regulates sonic hedgehog signalling during human intervertebral disc development and degeneration
Notochord-derived cells (NCs) in the developing nucleus pulposus (NP) maintain its hydrated extracellular matrix, essential for the shock-absorbing function of the intervertebral disc (IVD). The aging-associated loss of NCs initiates IVD degeneration, contributing to back pain. Despite their critica...
ORGANISM(S): Homo sapiens 
2025-12-08 | E-MTAB-15392 | biostudies-arrayexpress
TranscriptomicsTranscriptome changes affecting hedgehog and cytokine signalling in the umbilical cord in late pregnancy: implications for disease risk
BACKGROUND: Babies born at lower gestational ages or smaller birthweights have a greater risk of poorer health in later life. Both the causes of these sub-optimal birth outcomes and the mechanism by which the effects are transmitted over decades are the subject of extensive study. We investigated...
ORGANISM(S): Homo sapiens 
2012-09-24 | E-GEOD-37100 | biostudies-arrayexpress
TranscriptomicsGene expression in mice with conditional over-activation of hedgehog signaling in the ovary
The objective of the study was to determine the cause of anovulation in transgenic mice with conditional over-activation of the hedgehog signaling pathway in the ovary. In Amhr2(cre/+)-SmoM2 transgenic mice, a constitutively active version of the hedgehog signal transducer, smoothened (SMO), known ...
ORGANISM(S): Mus musculus 
2012-03-14 | E-GEOD-35123 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of conditional ablation of Indian hedgehog in the mouse uterus
Conditional ablation of Indian hedgehog (Ihh) in the murine uterus results in mice that are sterile due to defects in embryo implantation. We performed microarray analysis on these mice at the time point at which the Ihh target genes are induced by the administration of exogenous hormone to mimic d...
ORGANISM(S): Mus musculus 
2010-03-06 | E-GEOD-19517 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses to Sonic Hedgehog pathway stimulation in in vitro derived neural progenitors
The objective of this study was to identify genes regulated by Sonic Hedgehog pathway stimulation in neural progenitors. Paired (parallel culture) triplicates of neuralized embryoid body cultures with and without Shh pathway stimulation (Ag1.3-treatment)
ORGANISM(S): Mus musculus 
2012-12-15 | E-GEOD-42565 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of HhAntag-treated pancreatic xenografts
Four vehicle-treated and four HhAntag-treated pancreatic xenograft tumors were profiled for gene expression changes using Affymetrix U133 Plus 2.0 and Affymetrix Mouse Genome 430 2.0 arrays. Keywords: comparative gene expression, hedgehog, hh A primary human pancreatic tumor xenograft (1051178-A) w...
ORGANISM(S): Homo sapiens 
2008-09-12 | E-GEOD-11981 | biostudies-arrayexpress
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