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GenomicsThreonine-4 of Mammalian RNA Polymerase II CTD is Targeted by Polo-like Kinase-3 and Required for Transcriptional Elongation
Eukaryotic RNA polymerase II (Pol II) has evolved an array of heptad repeats with the consensus sequence Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7 at the carboxy-terminal domain (CTD) of the large subunit (Rpb1). Differential phosphorylation of Ser2, Ser5, and Ser7 in the 5M-bM-^@M-^Y and 3M-bM-^@M-^Y regi...
ORGANISM(S): Homo sapiens 
2012-06-04 | E-GEOD-37519 | biostudies-arrayexpress
UnknownPatterns and associated factors of diabetes self-management: Results of a latent class analysis in a German population-based study.
Not available
S-EPMC7978380 | biostudies-literature
UnknownDiabetes self-management education programs: Results from a nationwide population-based study on characteristics of participants, rating of programs and reasons for non-participation.
Not available
S-EPMC11392325 | biostudies-literature
GenomicsTyrosine phosphorylation of RNA Polymerase II CTD is associated with antisense promoter transcription and active enhancers in mammalian cells
In mammals, the carboxy-terminal domain (CTD) of RNA polymerase (Pol) II consists of 52 conserved heptapeptide repeats containing the consensus sequence Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7. Post-translational modifications of the CTD coordinate the transcription cycle and various steps of mRNA matura...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-52914 | biostudies-arrayexpress
TranscriptomicsTranscription Initiation Platforms and GTF recruitment at tissue-specific enhancers and promoters
Recent works have shown that RNA Polymerase (Pol) II can be recruited to, and transcribe, distal regulatory regions. Here, we analyzed transcription initiation and elongation through genome-wide localization of Pol II, General Transcription Factors (GTFs) and active chromatin in developing T-cells. ...
ORGANISM(S): Mus musculus 
2011-05-20 | E-GEOD-29362 | biostudies-arrayexpress
UnknownStructural basis for activation of plasma-membrane Ca2+-ATPase by calmodulin.
Not available
S-EPMC6255812 | biostudies-literature
TranscriptomicsChromatin immunoprecipitation of yeast to assess changes in RNA Polymerase II, Ser5-P, and Ser7-P occupancy upon chemical inhibition of Kin28
Chromatin Immunoprecipitation to assess changes in RNA Polymerase II, Ser5-P, and Ser7-P occupancy in S. cerevisiae upon chemical inhibition of Kin28
ORGANISM(S): Saccharomyces cerevisiae 
2009-07-01 | E-TABM-689 | biostudies-arrayexpress
TranscriptomicsCTD tyrosine phosphorylation impairs termination factor recruitment to transcribing RNA polymerase II
ChIP-chip was performed to identify the genomic binding locations for the termination factors Nrd1, and Rtt103, and for RNA polymerase (Pol) II phosphorylated at the tyrosine 1 and threonine 4 position of its C-terminal domain (CTD). In different phases of the transcription cycle, Pol II recruits di...
ORGANISM(S): Saccharomyces cerevisiae 
2012-06-29 | E-MTAB-1060 | biostudies-arrayexpress
UnknownMultisystem Inflammatory Syndrome in U.S. Children and Adolescents.
Not available
S-EPMC7346765 | biostudies-literature
UnknownChanges in Distribution of Severe Neurologic Involvement in US Pediatric Inpatients With COVID-19 or Multisystem Inflammatory Syndrome in Children in 2021 vs 2020.
Not available
S-EPMC9641594 | biostudies-literature
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