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TranscriptomicsChromatin occupancy and target genes of TCF7L2 in hepatocytes
TCF7L2 regulates multiple metabolic pathways in hepatocytes through a transcriptional network involving HNF4M-NM-1 For the identification of Tcf7l2 target genes using a RNA-seq timecourse, and for identifying the binding sites of Tcf7l2 and Hnf4a, Tcf7l2 was silenced in rat H4IIE hepatocytes using s...
ORGANISM(S): Rattus norvegicus 
2014-11-24 | E-GEOD-53862 | biostudies-arrayexpress
TranscriptomicsVitamin D receptor (VDR) target genes in THP-1 monocytic leucemia cells
The biologically active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), is a direct regulator of gene transcription, since it is the only high affinity natural ligand of the transcription factor vitamin D receptor (VDR). Transcriptome-wide analysis of THP-1 human monocyte-like cells had i...
ORGANISM(S): Homo sapiens 
2015-04-26 | E-GEOD-60102 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of vitamin D receptor (VDR) target genes in THP-1 monocytic leucemia cells
Identification of primary target genes of vitamin D receptor (VDR) in an immune-related cellular model (THP-1 cells) to study, in conjunction with VDR binding data from ChIP-seq, the genome-wide mechanisms of transcriptional regulation by VDR. THP-1 cells were treated 4 h either with 0.1% ethanol (v...
ORGANISM(S): Homo sapiens 
2011-08-16 | E-GEOD-27270 | biostudies-arrayexpress
GenomicsGenome-wide analysis of SUMOylation effects on androgen receptor (AR) binding in PC-3 cells (ChIP-seq)
Androgen receptor (AR) plays an important regulatory role during prostate cancer development. ARM-bM-^@M-^Ys transcriptional activity is regulated by androgenic ligands, but also by post-translational modifications. To study the role of the AR SUMOylation in genuine chromatin environment, we compare...
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-54110 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of androgen receptor (AR) SUMOylation effects on gene expression (HEK293).
Androgen receptor (AR) plays an important regulatory role during prostate cancer development. ARM-bM-^@M-^Ys transcriptional activity is regulated by androgenic ligands, but also by post-translational modifications. To study the role of the AR SUMOylation in genuine chromatin environment, we compare...
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-54137 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of androgen receptor (AR) SUMOylation effects on gene expression (PC-3).
Androgen receptor (AR) plays an important regulatory role during prostate cancer development. ARM-bM-^@M-^Ys transcriptional activity is regulated by androgenic ligands, but also by post-translational modifications. To study the role of the AR SUMOylation in genuine chromatin environment, we compare...
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-54104 | biostudies-arrayexpress
GenomicsGenome-wide analysis of SUMOylation effects on androgen receptor (AR) binding in HEK293 cells (ChIP-seq)
Androgen receptor (AR) plays an important regulatory role during prostate cancer development. ARM-bM-^@M-^Ys transcriptional activity is regulated by androgenic ligands, but also by post-translational modifications. To study the role of the AR SUMOylation in genuine chromatin environment, we compare...
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-54109 | biostudies-arrayexpress
GenomicsPatterns of genome-wide VDR locations
The genome-wide analysis of the binding sites of the transcription factor vitamin D receptor (VDR) is essential for a global appreciation the physiological impact of the nuclear hormone 1M-NM-1,25-dihydroxyvitamin D3 (1,25(OH)2D3). Genome-wide analysis of lipopolysaccharide (LPS)-polarized THP-1 hu...
ORGANISM(S): Homo sapiens 
2014-11-14 | E-GEOD-53041 | biostudies-arrayexpress
GenomicsEstrogen-responsive Estrogen Receptor alpha binding sites in MCF-7 by ChIP-seq
Identification of Estrogen Receptor alpha (ERa) binding sites by ChIP-seq in MCF-7 breast cancer cells following an estrogen treatment. This study describes molecular effects of estradiol treatment and subsequent regulation by ER for a single gene/locus. A public ER chipseq (available in SRA as ERR0...
ORGANISM(S): Homo sapiens 
2012-12-17 | E-GEOD-34759 | biostudies-arrayexpress
GenomicsGenome-wide landscape of liver X receptor chromatin binding and gene regulation
Gene expression: Identification of primary target genes of liver X receptor (LXR) in an immune-related cellular model (THP-1 cells) to study, in conjunction with LXR binding data from ChIP-seq, the genome-wide mechanisms of transcriptional regulation by LXR. ChIP-Seq: We performed ChIP-seq in macro...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-28319 | biostudies-arrayexpress
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