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ProteomicsComparison of unit resolution versus high-resolution accurate mass for parallel reaction monitoring
Parallel reaction monitoring (PRM) is an increasingly popular alternative to selected reaction monitoring (SRM) for targeted proteomics. PRM’s strengths over SRM are that it monitors all product ions in a single spectrum, thus eliminating the need to select interference-free product ions prior to da...
ORGANISM(S): Homo Sapiens 
PXD023334 | panorama
ProteomicsDynamic Data Independent Acquisition Mass Spectrometry with Real-Time Retrospective Alignment
We report a data independent acquisition (DIA) strategy that dynamically adjusts the tandem mass spectrometry (MS/MS) windows during the chromatographic separation. The method focuses MS/MS acquisition on the most relevant mass range at each point in time – improving the quantitative sensitivity by ...
ORGANISM(S): Homo Sapiens 
PXD038508 | panorama
ProteomicsEvaluating the Performance of the Astral Mass Analyzer for Quantitative Proteomics Using Data Independent Acquisition
We evaluate the quantitative performance of the newly released Asymmetric Track Lossless (Astral) analyzer. Using data independent acquisition, the Orbitrap Astral mass spectrometer quantifies 5 times more peptides per unit time than state-of-the-art Orbitrap mass spectrometers, which have long been...
ORGANISM(S): Homo Sapiens 
PXD042704 | panorama
ProteomicsLinear Ion Trap Global to Targeted Proteomics: A workflow for targeted proteomics assay development using a versatile linear ion trap
Advances in proteomics and mass spectrometry have enabled the study of limited cell populations, such as single-cell proteomics, where high-mass accuracy instruments are typically required. While triple quadrupoles offer fast and sensitive nominal resolution measurements, these instruments are effec...
ORGANISM(S): Mus Musculus 
PXD052847 | panorama
ProteomicsAlzheimer's Disease Isomerization
Amino acid isomerization is a spontaneous chemical modification potentially related to the underlying causes of Alzheimer’s disease (AD). We demonstrate that data-independent acquisition mass spectrometry can be used to characterize isomerization in complex protein mixtures. Examination of a large c...
ORGANISM(S): Homo Sapiens 
2022-03-16 | PXD025668 | panorama
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