Sort   by:  
 Page size 
TranscriptomicsDNA-targeted platinum-acridine anticancer agents
Yeast homozygous and essential heterozygous deletion mutants were screened against novel platinum-containing compounds
ORGANISM(S): Schizosaccharomyces pombe 
2012-08-28 | E-MTAB-1267 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast homozygous and essential heterozygous diploid deletion strains screened with 3-nitroso-imidazo[1,2-a]pyridines and -pyrimidines to identify gene deletions that confer sensitivity to each compound
The complete pool of barcoded homozygous and essential heterozygous diploid deletion strains of S. cerevisiae were screened with 3-nitroso-imidazo[1,2-a]pyridines and -pyrimidines to identify gene deletions that confer sensitivity to each compound.
ORGANISM(S): Saccharomyces cerevisiae 
2008-09-19 | E-TABM-560 | biostudies-arrayexpress
TranscriptomicsDosage Suppression Genetic Interaction Networks
A functionally diverse subset of yeast temperatures sensitive deletion mutants were transformed with a pool of barcoded yeast ORFs to identify dosage suppressors. Objective: To assess the relative strain proportion after growing DNA barcoded yeast deletion strains in a mixed pools. The barcodes are...
ORGANISM(S): Saccharomyces cerevisiae 
2012-04-21 | E-TABM-1147 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of yeast heterozygous diploid deletions strains screened with 20 compounds to identify gene deletions that confer sensitivity to each compound
The complete pool of barcoded essential heterozygous diploid deletion strains of S. cerevisiae were screened with 20 compounds from the Chembridge NOVACore chemical library to identify gene deletions that confer sensitivity to each compound.
ORGANISM(S): Saccharomyces cerevisiae 
2011-04-13 | E-TABM-977 | biostudies-arrayexpress
TranscriptomicsHaploinsufficiency profiling by array of yeast heterozygous transposon disruption mutants grown in the presence of different synthetic compounds
A pool of 3633 tagged heterozygous transposon disruption mutants underwent haploinsufficiency profiling in the presence of different synthetic compounds to identify their cellular targets
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-30 | E-MTAB-398 | biostudies-arrayexpress
TranscriptomicsStrain abundance assay of 3633 Candida albicans heterozygous transposon disruption mutants grown in YPD, SC, YNB or SLAD media
A pool of 3633 tagged heterozygous transposon disruption mutants underwent haploinsufficiency profiling in different media conditions (YPD, SC, YNB, and SLAD) to identify slow growing strains in these conditions.
ORGANISM(S): Candida albicans 
2011-09-30 | E-TABM-1080 | biostudies-arrayexpress
TranscriptomicsNucleosomal occupancy in a SNF2 deletion
Nucleosomal preparations generated by micorcoccal nuclease digestion were analyzed on Affymetrix tiling arrays to determine changes in occupancy after deletion of the SNF2 gene
ORGANISM(S): Saccharomyces cerevisiae 
2011-04-08 | E-TABM-1141 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD4+/CD8+ T cells obtained from HIV patients at various stages of disease vs. uninfected individuals reveals HIV infection induces a persistent T cell transcriptional profile
We examined the gene expression profiles in ex vivo human CD4+ and CD8+ T cells from untreated HIV-infected individuals at different clinical stages and rates of disease progression. Profiles of pure CD4+ and CD8+ T cells subsets from HIV-infected nonprogressors who controlled viremia were indisting...
ORGANISM(S): Homo sapiens 
2007-11-11 | E-GEOD-6740 | biostudies-arrayexpress
Genomics293_hORF3.1_drug_treatments_partIII
The human ORFeome collection version 3.1 was stably integrated into HEK293 (lentivirus based). The cells harboring the collection were harvested, collection specific DNA was amplified and sequenced to assess the collection representation.
ORGANISM(S): Homo sapiens 
2014-05-15 | E-MTAB-2498 | biostudies-arrayexpress
TranscriptomicsMultiple means to the same end: The genetic basis of acquired stress resistance in yeast
A series of experiments comparing the gene expression response before and after 30 min 0.7M NaCl exposure in WT and mutant yeast strains. Mutant strains were identified as having a defect in acquiring resistance to H2O2 following mild NaCl pretreatment. The mutants in this study were taken from the ...
ORGANISM(S): Saccharomyces cerevisiae 
2014-03-06 | E-GEOD-27819 | biostudies-arrayexpress
Sort   by:  
 Page size