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ProteomicsThe AdipoR2 protein recruits an ER-localized fatty acid elongation complex to promote membrane homeostasis
The human AdipoR2 protein and its C. elegans homolog PAQR-2 are multi-pass plasma membrane proteins that protect cells against membrane rigidification. We seek to better understand the mechanisms by which these proteins can promote the synthesis and incorporation of membrane-fluidizing unsaturated f...
ORGANISM(S): Homo sapiens (Human) Caenorhabditis elegans 
2023-07-20 | PXD031395 | Pride
Paqr-2 Phospholipids C.elegans Human Adipor2 
TranscriptomicsTranscriptome wide identification of Dicer binding in human and C. elegans reveals a variety of substrates (CEL RNA-Seq)
Dicer is a deeply conserved endoribonuclease with key functions in small RNA biogenesis. Here we employed PAR-CLIP/iPAR-CLIP to identify direct Dicer binding sites in the transcriptomes of human cells and C.elegans. We found hundreds of novel miRNAs and non-canonical Dicer substrates with high sensi...
ORGANISM(S): Caenorhabditis elegans 
2014-11-20 | E-GEOD-55329 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cells embryonic kidney cells (HEK 293 cell line) overexpressing different isoforms of hIMP1 protein
Regulation of presenilin genes. Presenilins are intramembrane aspartic proteases. These proteases are critical proteins in pathogenesis of Alzheimer's disease. The function of recently identified presenilin-homologous proteases (IMPAS or SPP)s is unknown. Our preliminary data in C.elegans model sugg...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6276 | biostudies-arrayexpress
ProteomicsMechanisms of stop codon readthrough mitigation reveal principles of GCN1 mediated translational quality control
Readthrough into the 3′ untranslated region (3′UTR) of the mRNA results in the production of aberrant proteins. Metazoans efficiently clear readthrough proteins, but the underlying mechanisms remain unknown. Here, we show in C. elegans and mammalian cells that readthrough proteins are targeted by a ...
ORGANISM(S): Homo sapiens (Human) Caenorhabditis elegans 
2023-06-09 | PXD037037 | Pride
Hek293 c.elegans 
GenomicsCaenorhabditis elegans
Transcriptome wide identification of Dicer binding in human and C. elegans reveals a variety of substrates (CEL RNA-Seq)
PRJNA239338 | ENA
GenomicsMechanisms of stop codon readthrough mitigation reveal principles of GCN1 mediated translational quality control
Mechanisms of stop codon readthrough mitigation reveal principles of GCN1 mediated translational quality control
PRJNA885130 | ENA
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