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ProteomicsSCX, 18O-labeling and charge reversal for C-terminomics
The proteome wide, mass spectrometry based identification of protein C-termini is hampered by factors such as poor ionization efficiencies, low yields in labeling strategies or the need for enrichment procedures. We present a bottom-up proteomics workflow to identify protein C-termini utilizing a co...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-06-20 | PXD013486 | Pride
Lc-ms Charge-reversal derivatization C-terminomics 
ProteomicsExopeptidase assisted N- and C-terminal proteome sequencing
Due to mechanisms such as alternative translation starts or proteolytic processing, in-vivo proteoforms do not necessarily correspond to those encoded in the genome. Therefore, knowledge of protein termini is an indispensable prerequisite to understand protein function. Sequencing of protein N- and ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-10-15 | PXD015612 | Pride
Protein sequencing Proteomics Terminomics 
UnknownIdentification and characterization of novel filament-forming proteins in cyanobacteria.
Not available
S-EPMC7002697 | biostudies-literature
UnknownSepT, a novel protein specific to multicellular cyanobacteria, influences peptidoglycan growth and septal nanopore formation in Anabaena sp. PCC 7120.
Not available
S-EPMC10653889 | biostudies-literature
UnknownLoss of function of the retinoid-related nuclear receptor (RORB) gene and epilepsy.
Not available
S-EPMC5117930 | biostudies-literature
ProteomicsThe E3 ubiquitin ligase HectD3 is a novel regulator of cardiac hypertrophy and inflammation
The HECT domain E3 ubiquitin protein ligase 3 (HectD3) is highly expressed in the heart, but its cardiac function is still unknown. Here, we identified SUMO2 and Stat1 as novel cardiac substrates for HectD3. SUMO2 is a potent inducer of Calcineurin-NFAT mediated cardiomyocyte hypertrophy, whereas, S...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-09 | PXD020843 | Pride
Ubiquitin ligase Cardiac models Proteomics 
UnknownMutations in PMPCB Encoding the Catalytic Subunit of the Mitochondrial Presequence Protease Cause Neurodegeneration in Early Childhood.
Not available
S-EPMC5985287 | biostudies-literature
UnknownRARS1-related hypomyelinating leukodystrophy: Expanding the spectrum.
Not available
S-EPMC6952319 | biostudies-literature
UnknownBi-allelic variants in OGDHL cause a neurodevelopmental spectrum disease featuring epilepsy, hearing loss, visual impairment, and ataxia.
Not available
S-EPMC8715183 | biostudies-literature
UnknownGenetic heterogeneity in infantile spasms.
Not available
S-EPMC6814289 | biostudies-literature
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