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MetabolomicsExtracts from sweet sorghum (Sorghum bicolor), a feedstock for biorefining, suppressed proliferation and elevated apoptosis in human colon cancer stem cells via suppression of Wnt/beta-catenin signaling pathway
In colorectal cancer, p53 is commonly inactivated, associated with chemo-resistance, and marks the transition from non-invasive to invasive disease. Cancers, including colorectal cancer, are thought to be diseases of aberrant stem cell populations, as stem cells are able to self-renew, making them l...
2014-05-01 | MTBLS69 | MetaboLights
MetabolomicsTwo UGT84A Family Glycosyltransferases Regulate Phenol, Flavonoid, and Tannin Metabolism in Juglans regia (English Walnut)
We showed previously that gallic acid is produced in walnut from 3-dehydroshikimate by a shikimate dehydrogenase (JrSkDH). This study focuses on the next step in the hydrolysable tannin pathway, the formation of 1-O-galloyl-β-D-glucose from the phenolic gallic acid and UDP glucose by a glycos...
2022-10-11 | MTBLS2042 | MetaboLights
MetabolomicsLipid Data Analyzer: Analysis of a complex biological system from murine liver samples (Murine liver lipidome experiment)
Lipid Data Analyzer (LDA; http://genome.tugraz.at/lda2) provides automated and reliable annotation of lipid species and their molecular structures in high-throughput data from chromatography-coupled tandem mass spectrometry using embedded rule sets. Using various low- and high-resolution mass spectr...
2017-11-07 | MTBLS396 | MetaboLights
TranscriptomicsBrd7, a novel PBAF-specific SWI/SNF subunit, is required for gene activation and repression in embryonic stem cells
The composition of chromatin remodeling complexes dictates how these enzymes control transcriptional programs and cellular identity. Here, we investigate the composition of SWI/SNF complexes in embryonic stem cells (ESCs). In contrast to differentiated cells, ESCs have a biased incorporation of cert...
ORGANISM(S): Mus musculus 
2010-03-04 | E-GEOD-7791 | biostudies-arrayexpress
TranscriptomicsOxygen regulation of immunogenicity in primary human glioma cells
Dendritic Cell (DC) vaccination is a powerful approach for cancer immunotherapy that has recently obtained regulatory approval, and tumor lysate-pulsed DC vaccines are being tested in clinical trials. Tumor cell lysates (TLs) are often generated from cells cultured in atmospheric oxygen (~20% O2), w...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-28316 | biostudies-arrayexpress
MetabolomicsDiscovering potential urinary biomarkers of tomato consumption using untargeted metabolomics
Tomatoes are one of the most consumed vegetables in the United States, making them an economically and nutritionally important crop. Previous epidemiological and intervention studies have suggested positive health outcomes associated with tomato consumption. To more conclusively understand the relat...
2024-11-04 | MTBLS2328 | MetaboLights
TranscriptomicsSpalax gene expression profiling of muscle and brain under hypoxia
Spalax, an underground fossoral rodant is exposed to chronic hypoxic environments. Measurements of Spalax burrows indicated 7% oxygen and up to 15% CO2. In the laboratory Spalax can survive 3% oxygen up to 14 hours as compared to rats that survive less than 4 hours at these oxygen levels. we have pr...
ORGANISM(S): Rattus norvegicus 
2012-12-31 | E-GEOD-37619 | biostudies-arrayexpress
TranscriptomicsM. sedula transcriptional response under "strict" carbon-limited autotrophy compared to carbon "rich" autotrophy and heterotrophy
Metallosphaera sedula is an extremely thermoacidophilic archaeon that grows heterotrophically on peptides, and chemolithoautotrophically on hydrogen, sulfur, or reduced metals as energy sources. During autotrophic growth, carbon dioxide is incorporated into cellular carbon via the 3-hydroxypropionat...
ORGANISM(S): Metallosphaera sedula DSM 5348 
2013-03-05 | E-GEOD-39944 | biostudies-arrayexpress
UnknownROSIE: AI generation of multiplex immunofluorescence staining from histopathology images.
Not available
S-EPMC12357954 | biostudies-literature
ProteomicsU1 snRNP and RNA polymerase II interaction is predominantly mediated by Prp40 rather than U1-70K in yeast
Transcription and splicing are coupled both temporally and physically. A previous cryo-EM structure of the human U1 snRNP and RNA polymerase pol II complex has shown that U1 snRNP uses predominantly the RRM domain of U1-70K to directly interact with the RPB2 subunit of pol II. However, residues on U...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-05-20 | PXD078573 | Pride
Yeast Spliceosome Splicing Pol ii Snrnp Prp40 
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