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ProteomicsMolecular insights into RNA polymerase recycling by mycobacterial HelD
Mycobacterial HelD is a transcription factor that binds RNA polymerase (RNAP) and thereby rescues it from stalled transcription complexes. HelD also protects RNAP against the antibiotic rifampicin. HelD, however, must be released from the rescued RNAP to participate in the next round of the transcri...
ORGANISM(S): Mycobacterium smegmatis 
2024-10-08 | PXD046632 | Pride
Held  rna polymerase  mycobacteria  transcription  rifampicin 
TranscriptomicsRNA-seq of Mycobacterium smegmatis mc2 155 wild type and helD (MSMEG_2174) deletion strain, exponential and stationary phase cells
HelD (MSMEG_2174) is an RNA polymerase interaction partner in Mycobacterium smegmatis. We assume that this protein might be involved in the regulation of gene expression by sensing a level of nucleotides in the cell. To address the role of helD, we generated a deletion strain. Our aim was to see the...
ORGANISM(S): Mycolicibacterium smegmatis 
2026-10-08 | E-MTAB-13810 | biostudies-arrayexpress
TranscriptomicsInhibition of endogenous MTF-1 signaling in zebrafish embryos identifies novel roles for MTF-1 in development
The MTF-1 transcription factor is considered to be a master regulator of zinc homoestasis. We previously characterized a constitutively nuclear, dominant-negative zebrafish MTF-1/eGFP fusion protein (dnMTF-1). In this study, in vitro transcribed dnMTF-1 mRNA was microinjected into zebrafish embryos ...
ORGANISM(S): Danio rerio 
2014-04-25 | E-GEOD-51298 | biostudies-arrayexpress
MetabolomicsImproving the Screening Analysis of Pesticide Metabolites in Human Biomonitoring by Combining High-Throughput In Vitro Incubation and Automated LC-HRMS Data Processing
There is a current need to monitor human exposure to a large number of pesticides and other chemicals of emerging concern (CECs). This requires screening analysis with high confidence for these compounds and their metabolites in complex matrices, which is hampered by the fact that no reference stand...
2022-01-17 | MTBLS2402 | MetaboLights
MetabolomicsTwo Poplar-Associated Bacterial Isolates Induce Additive Favorable Responses in a Constructed Plant-Microbiome System
The biological function of the plant-microbiome system is the result of contributions from the host plant and microbiome members. The Populus root microbiome is a diverse community that has high abundance of β- and γ-Proteobacteria, both classes which include multiple plant-growth promoting represen...
2017-07-25 | MTBLS332 | MetaboLights
TranscriptomicsMemory-like CD8 T-cells sustain the immune response to chronic viral infections.
We have discovered a small subpopulation of virus-specific CD8 T-cells that sustains the T-cell response in chronic infections. These cells are defined by - and depend on - the expression of the transcription factor Tcf1 (T cell factor 1) and show key characteristics of central memory cells while ...
ORGANISM(S): Mus musculus 
2016-08-22 | E-GEOD-83978 | biostudies-arrayexpress
MetabolomicsA data integration multi-omics approach to study calorie restriction-induced changes in insulin sensitivity
The mechanisms responsible for weight loss-induced improvement in insulin sensitivity are partially understood. Greater insight can now be achieved through deep phenotyping and data integration. Here, we used an integrative approach to investigate associations between changes in insulin sensitivity ...
2021-02-11 | MTBLS653 | MetaboLights
UnknownFunctional implications of glycans and their curation: insights from the workshop held at the 16th Annual International Biocuration Conference in Padua, Italy.
Not available
S-EPMC11321244 | biostudies-literature
ProteomicsExploring the early molecular pathogenesis of osteoarthritis using differential network analysis of human synovial fluid
This MS data set was used as validation data for an exploratory proteomics study of biomarkers in osteoarthritis (OA) using SOMAscan assay data. We analyzed human synovial fluid from three groups with the two methods: 1) deceased donors with mildly degenerated cartilage and/or meniscus, which is a w...
ORGANISM(S): Homo sapiens (Human) 
2024-05-13 | PXD051182 | Pride
Human Osteoarthritis Synovial fluid 
MetabolomicsOsmolality-based normalization enhances statistical discrimination of untargeted metabolomic urine analysis: results from a comparative study

INTRODUCTION: Because of its ease of collection, urine is one of the most commonly used matrices for metabolomics studies. However, unlike other biofluids, urine exhibits tremendous variability that can introduce confounding inconsistency during result interpretation. Despite man...

2023-09-04 | MTBLS1765 | MetaboLights
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