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GenomicsGenome binding profile of TFIIH helicases XPB and XPD in HT1080 cells
The conserved TFIIH helicases XPB and XPD play key roles in transcription initiation and DNA repair. To investigate the functions of these helicases on a genome-wide scale, we performed ChIP-seq of endogenous XPB and XPD in the HT1080 human fibrosarcoma cell line. 2 ChIP samples and 1 unenriched inp...
ORGANISM(S): Homo sapiens 
2014-02-18 | E-GEOD-44849 | biostudies-arrayexpress
ProteomicsDEAD box RNA helicases are pervasive protein kinase interactors and activators
DEAD box (DDX) RNA helicases are a large family of ATPases, many of which have unknown functions. There is emerging evidence that besides their role in RNA biology, DDX proteins may stimulate protein kinases. To investigate if protein kinase-DDX interaction is a more widespread phenomenon, we conduc...
ORGANISM(S): Homo sapiens (Human) 
2024-03-10 | PXD043289 | Pride
Kinase activators Rna helicases Interactome 
TranscriptomicsRad53-mediated regulation of Rrm3 and Pif1 DNA helicases contributes to prevention of aberrant fork transitions under replication stress.
Replication stress activates the Mec1ATR and Rad53 kinases. Rad53 phosphorylates nuclear pores to counteract gene gating, thus preventing aberrant transitions at forks approaching transcribed genes. Here, we show that Rrm3 and Pif1, DNA helicases assisting fork progression across pausing sites, are ...
ORGANISM(S): Saccharomyces cerevisiae 
2015-09-24 | E-GEOD-68214 | biostudies-arrayexpress
TranscriptomicsSplicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness
Both epigenetic and splicing regulation contribute to tumor progression, but the potential links between these two levels of gene-expression regulation in pathogenesis are not well understood. Here, we report that the mouse and human RNA helicases ddx17 and ddx5 contribute to tumor-cell invasiveness...
ORGANISM(S): Mus musculus 
2012-09-11 | E-GEOD-40737 | biostudies-arrayexpress
GenomicsPlakophilin 1 suppresses keratinocyte innate immune responses through DExD/H helicases
Plakophilin 1 suppresses keratinocyte innate immune responses through DExD/H helicases
PRJNA1279987 | ENA
GenomicsWidespread genomic/molecular alterations of DNA helicases and their clinical/therapeutic implications across human cancer
Widespread genomic/molecular alterations of DNA helicases and their clinical/therapeutic implications across human cancer
PRJNA898782 | ENA
UnknownSuperfamily 2 helicases.
Not available
S-EPMC3775597 | biostudies-literature
ProteomicsIdentification of RNA helicases that mediate processing of tRNAs into distinct tRNA fragments by LC-MS/MS.
Specific environmental insults cause the limited fragmentation of transfer RNAs (tRNAs) into tRNA-derived small RNAs (tsRNAs), which have been implicated in a wide range of biological processes. tRNA fragmentation results from endonucleolytic activities targeting single-stranded tRNA regions. Howeve...
ORGANISM(S): Homo sapiens (Human) 
2023-01-09 | PXD029869 | Pride
Ddx5x Trna fragments Ddx3x Tsrna Rna helicase enzymes 
UnknownMechanisms of hexameric helicases.
Not available
S-EPMC9869668 | biostudies-literature
UnknownGenome-wide comprehensive analysis of human helicases.
Not available
S-EPMC3073292 | biostudies-literature
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