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ProteomicsUbiquitination of DEAD-box RNA helicase DDX3X by TRIM25
Tripartite motif protein 25 (TRIM25) is an E3 ligase that ubiquitinates multiple substrates within the RLR signalling cascade and plays both RING (really interesting new gene)-dependent and RING-independent roles in RIG-I-mediated IFN induction. We report that the PRY-SPRY domain of TRIM25 interacts...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD028122 | Pride
Ddx3x Trim25 Ubiquitin 
ProteomicsDDX3X associated proteins with or without circRIG-I
We use FLAG pulldown assay to find DDX3X associated proteins with or without circRIG-I in HEK293T.
ORGANISM(S): Homo sapiens (Human) 
2022-11-16 | PXD037929 | Pride
Ddx3x Circrig-i Hek293t 
TranscriptomicsMolecular insights into DDX3X–mRNA regulation in castration-resistant prostate cancer
RNA-immunoprecipitation sequencing (RIP-seq) was performed to identify the transcripts under the regulation of DEAD-box helicase 3 X-linked (DDX3X). The BPH1-derived Cancer Progression (BCaP) cell lines were used for RIP-seq. Input and RIP RNA from the androgen receptor low/negative castration-resis...
ORGANISM(S): Homo sapiens 
2026-04-17 | E-MTAB-15800 | biostudies-arrayexpress
ProteomicsDDX3X SUMOylation Promotes Septic Inflammation by Enhancing NLRP3 Inflammasome Activation
This study investigates the role of DDX3X SUMOylation in the activation of the NLRP3 inflammasome during sepsis. We demonstrate that SUMOylation of DDX3X, regulated by the SUMO protease SENP1, is a crucial trigger for NLRP3 inflammasome activation. In endotoxemia and sepsis models, the absence of SE...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-06 | PXD060598 | Pride
Lc-ms 
ProteomicsSex specific pertubations of neuronal development caused by mutations in the autism risk gene DDX3X
DDX3X is an X-linked RNA helicase that escapes X chromosome inactivation and is expressed at higher levels in female brains. Mutations in DDX3X are associated with intellectual disability (ID) and autism spectrum disorder (ASD) and are predominantly identified in females. Using cellular and mouse mo...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-26 | PXD060033 | Pride
Sex differences  neuronal development  dendritic spines  mrna translation  motor behavior  autism  ddx3x  nucleolus  ribosome biogenesis 
GenomicsMedulloblastoma associated DDX3X mutants restore malignant potential of medulloblastoma cells decreased upon the loss of DDX3X expression
Medulloblastoma associated DDX3X mutants restore malignant potential of medulloblastoma cells decreased upon the loss of DDX3X expression
PRJNA833872 | ENA
GenomicsTranscriptome profiling of DDX3X/DDX3Y dependency after DDX3X gRNA targeting in KNS-42 parental cell lines, and rescue experiments with DDX3X or DDX3Y overexpressing cells (PACT).
Transcriptome profiling of DDX3X/DDX3Y dependency after DDX3X gRNA targeting in KNS-42 parental cell lines, and rescue experiments with DDX3X or DDX3Y overexpressing cells (PACT).
PRJNA787308 | ENA
TranscriptomicsiCLIP of DDX3X and DDX54 in human breast cancer MCF7 cells
Individual nucleotide resolution cross-linking immunoprecipitation (iCLIP) detects protein-RNA binding sites at a single nucleotide resolution. We aimed to identify the transcripts directly bound to DDX3X and DDX54 in human breast cancer MCF7 cells and to characterize the site of interaction at a si...
ORGANISM(S): Homo sapiens 
2018-11-21 | E-MTAB-6230 | biostudies-arrayexpress
ProteomicsRNA Helicase DDX3X Modulates Herpes Simplex Virus 1 Nuclear Egress
DDX3X is a mammalian RNA helicase that regulates RNA metabolism, cancers, innate immunity and several RNA viruses. We discovered that herpes simplex virus 1, a nuclear DNA replicating virus, highjacks redirects DDX3X to the nuclear envelope where it surprisingly modulates the exit of newly assembled...
ORGANISM(S): Homo sapiens (Human) 
2023-02-21 | PXD039403 | Pride
Herpesvirus Nec Hsv Helicase Herpes Ddx Ddx3 Host-pathogen interaction Us3 Ul31 
ProteomicsDDX3X Acts as a Live or Die Checkpoint in Stressed Cells by Regulating NLRP3 Inflammasome
The cellular stress response plays a vital role in regulating homeostasis by modulating cell survival and death. Stress granules (referred to as SGs) are cytoplasmic compartments that allow cells to survive various stressors. Defects in SG assembly and disassembly have been found to play important r...
ORGANISM(S): Mus musculus (Mouse) 
2019-10-03 | PXD014828 | Pride
Il-18 Caspase-1 Ddx3x Inflammasome Proinflammatory cytokines Pyroptosis Stress granules Il-1β Cytoplasmic compartments Asc specks Nlrp3 
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