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MetabolomicsA metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance
Tissues are exposed to diverse inflammatory challenges that shape future inflammatory responses. While cellular metabolism regulates immune function, how metabolism programs and stabilizes immune states within tissues and tunes susceptibility to inflammation is poorly understood. Here, we describe a...
2024-10-25 | MTBLS10416 | MetaboLights
TranscriptomicsExpression data of IL-18 generated murine NK cells
We analyzed gene expression profiles of IL-18 generated murine NK cells in comparison to unstimulated, freshly isolated splenic NK cells. We identified a set of 1414 Affymetrix probe sets showing significant misregulation (Welch's T-test, p<0.05; Benjamini-Hochberg FDR corrected). IL-18 generated as...
ORGANISM(S): Mus musculus 
2012-07-10 | E-GEOD-33627 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse IL-18 knockouts vs. wild types treated with pressure overload to examine cardiac hypertrophy
Pressure overload-induced cardiac hypertrophy was examined in IL-18 knockout and littermate control mice. Experiment Overall Design: 4 groups with RNA pooled from 5-6 per group. Role of IL-18 on gene expression in cardiac hypertrophy induced by pressure overload (transaortic constriction)
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5129 | biostudies-arrayexpress
TranscriptomicsTranscriptional changes in IL-2, IL-12 and IL-18 stimulated human natural killer cells
We used Affymetrix expression arrays to determine changes in gene expression associated with activation of human NK cells mediated through treatment with cytokines IL-2, IL-12 and IL-18 over a 24 hour period. Human natural killer cells were isolated via negative selection from PBMCs of healthy donor...
ORGANISM(S): Homo sapiens 
2010-08-05 | E-GEOD-22919 | biostudies-arrayexpress
TranscriptomicsIL-18 Inhibition Aggravates Atherosclerosis in Jak2V617F Clonal Hematopoiesis
Clonal hematopoiesis (CH) driven by Jak2V617F is known to accelerate atherosclerosis through inflammasome activation and release of IL-1β and IL-18, yet the specific contribution of IL-18 has remained unclear. In this study, we demonstrate that antibody inhibition of IL-18 in Jak2V617F CH mice incre...
ORGANISM(S): Mus musculus 
2025-10-30 | E-MTAB-15736 | biostudies-arrayexpress
GenomicsRNAseq analysis of IL-18 WT- and IL-18 D69A-overexpressing B16-F10 tumors
RNAseq analysis of IL-18 WT- and IL-18 D69A-overexpressing B16-F10 tumors
PRJNA1044102 | ENA
ProteomicsMembrane IL-18 Identifies a Unique Human Macrophage Subset with Distinct Phenotypic and Functional Properties
This study adds a tile to the macrophage heterogeneity in humans. We characterize a unique macrophage population expressing membrane-associated IL-18 (mIL-18) that shows peculiar proteomic, phenotypic, ultrastructural, and functional properties. mIL-18+ macrophages exhibit increased levels of key pr...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD058726 | Pride
Il-18 Macrophages Adult cancer patients  pediatric neuroblastoma Endocytosis Trem2 
TranscriptomicsATF3 is a positive regulator of human IFN gene expression
The aim of this study was to identify genes regulated by IL-12, IL-18 and IFN-alpha during early differentiation of human Th1 cells Human cord blood CD4+ T cells were activated via TCR and cultured in the presence of IL-12, IFN-alpha or IL-12+IL-18. Cytokine induced gene expression was compared to a...
ORGANISM(S): Homo sapiens 
2010-04-11 | E-GEOD-20198 | biostudies-arrayexpress
GenomicsRNA squencing of human NK cells activated with IL-15, a combination of IL-12, IL-15, and IL-18, or with a trimeric fusion protein 18/12/TxM
RNA squencing of human NK cells activated with IL-15, a combination of IL-12, IL-15, and IL-18, or with a trimeric fusion protein 18/12/TxM
PRJNA699884 | ENA
TranscriptomicsTranscription profiling by array of human rheumatoid fibroblast-like synoviocytes to study the role of micro RNAs in IL-18 synthesis regulation
Study of the role of micro RNAs in IL-18 synthesis regulation in rheumatoid fibroblast-like synoviocytes (FLS)
ORGANISM(S): Homo sapiens 
2010-03-13 | E-MEXP-1970 | biostudies-arrayexpress
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