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MetabolomicsShi Wei Ru Xiang pill alleviates acute gouty arthritis through suppressing NLRP3 inflammasome activation

Shi Wei Ru Xiang pill (SWR) is commonly utilized in Tibetan medicine as a therapeutic intervention for 'Huang-shui disease' and has been clinically validated as an effective treatment for acute gouty arthritis (AGA). Nevertheless, the underlying mechanisms of action and the active components of S...

2025-06-20 | MTBLS12617 | MetaboLights
MetabolomicsNLRP3 Senses L-Arginine to Inhibit Inflammasome Activation and Alleviate Parkinson’s disease Pathology

We screened a series of metabolites and found that L-Arg strongly inhibits NLRP3 inflammasome assembly in vitro. Mechanistically, L-Arg directly binds the D31 site of NLRP3, blocking NLRP3-ASC interaction and subsequent inflammasome assembly. This discovery establishes NLRP3 as a direct sensor fo...

2026-09-02 | MTBLS13737 | MetaboLights
MetabolomicsA Bidirectional Regulatory ACLY-NLRP3 Axis Integrates Metabolic and Inflammatory Signaling to Control NLRP3 Inflammasome Activation

The NLRP3 inflammasome is critical for host defense against bacterial infection and is involved in the pathogenesis of various inflammatory diseases. The aggregation of its sensor protein NLRP3 is a pivotal checkpoint for inflammasome activation. Howev...

2026-01-07 | MTBLS13400 | MetaboLights
MetabolomicsGlucose flux analysis of NLRP3 inflammasome activated macrophages
Not available
ORGANISM(S): Mus musculus 
ST002379 | MetabolomicsWorkbench
MetabolomicsHigh-resolution metabolomics analysis of NLRP3 inflammasome activated macrophages
Not available
ORGANISM(S): Mus musculus 
ST002371 | MetabolomicsWorkbench
TranscriptomicsType I interferon signaling is required for activation of the inflammasome during Francisella infection
Francisella are pathogenic bacteria whose virulence is linked to their ability to replicate within the host cell cytosol. Entry into the macrophage cytosol activates a host protective multimolecular complex called the inflammasome to release the proinflammatory cytokines IL-1 and IL-18 and trigger c...
ORGANISM(S): Mus musculus 
2007-05-23 | E-GEOD-7684 | biostudies-arrayexpress
TranscriptomicsAn activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome
Inflammasomes are intracellular innate immune sensors that respond to pathogen and damage-associated signals with the proteolytic cleavage of caspase-1, resulting in IL-1_ and IL-18 secretion and macrophage pyroptosis. The discovery that heterozygous gain-of-function mutations in NLRP3 lead to overs...
ORGANISM(S): Homo sapiens 
2014-09-08 | E-GEOD-57253 | biostudies-arrayexpress
TranscriptomicsTNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP
The pediatric immune deficiency X-linked proliferative disease-2 (XLP-2) is a unique disease, with patients presenting with either hemophagocytic lymphohistiocytosis (HLH) or intestinal bowel disease (IBD). Interestingly, XLP-2 patients display high levels of IL-18 in the serum even while in stable ...
ORGANISM(S): Mus musculus 
2021-03-01 | E-MTAB-10103 | biostudies-arrayexpress
ProteomicsProteomic and bioinformatic characterization of proteins secreted conventionally and unconventionally from human primary macrophages upon LPS transfection
The non-canonical caspase-4/5 inflammasome has been only very recently characterized. It is expressed by macrophages, the principal effector cells of the innate immunity system, and is activated by gram-negative bacteria, ER stress, and UV radiation. Activation of this inflammasome results in pyropt...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080769 | MassIVE
TranscriptomicsGene expression profiling of interferon-beta stimulated cells
Cytoplasmic DNA triggers the activation of the innate immune system. While downstream signaling components have been characterized, the DNA sensing components remain largely elusive. We performed a systematic proteomics screen for proteins that associate with DNA, traversed to a screen for IFN-β-ind...
ORGANISM(S): Mus musculus 
2009-01-14 | E-GEOD-14413 | biostudies-arrayexpress
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