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ProteomicsUbiquitination of DEAD-box RNA helicase DDX3X by TRIM25
Tripartite motif protein 25 (TRIM25) is an E3 ligase that ubiquitinates multiple substrates within the RLR signalling cascade and plays both RING (really interesting new gene)-dependent and RING-independent roles in RIG-I-mediated IFN induction. We report that the PRY-SPRY domain of TRIM25 interacts...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD028122 | Pride
Ddx3x Trim25 Ubiquitin 
ProteomicsSubstrate trapping approach identifies TRIM25 ubiquitination targets involved in diverse cellular and antiviral processes
The tripartite motif (TRIM) family of E3 ubiquitin ligases is well known for its roles in antiviral restriction and innate immunity regulation, in addition to many other cellular pathways. In particular, TRIM25-mediated ubiquitination affects both carcinogenesis and antiviral response. While individ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-02 | PXD034024 | Pride
Ubiquitination Trim25 Lcms 
GenomicsTRIM25
TRIM25
PRJNA316328 | ENA
GenomicsExogenous RNA surveillance by proton-sensing TRIM25
Exogenous RNA surveillance by proton-sensing TRIM25
PRJNA1103110 | ENA
ProteomicsThe E3 ligase TRIM25 impairs apoptotic cell death in colon carcinoma cells through hnRNPH1-triggered destabilization of caspase-7 mRNA
Therapy resistance is still a major reason for treatment failure in colorectal cancer (CRC). Previously, we identified the E3 ubiquitin ligase TRIM25 as a novel suppressor of caspase-2 translation, thereby contributing to apoptosis resistance of CRC cells towards chemotherapeutic drugs. We herein re...
ORGANISM(S): Homo sapiens (Human) 
2023-01-05 | PXD037182 | Pride
Trim25 Colon carcinoma cells Caspase-7 Hnrnph1 Rna binding proteins Apoptosis 
GenomicsDegradation of AGO2 by TRIM25 drives cancer progression and chemotherapy resistance
Degradation of AGO2 by TRIM25 drives cancer progression and chemotherapy resistance
PRJNA1227454 | ENA
GenomicsDestruction of VISTA by TRIM25 ablation in T cells potentiates cancer immunotherapy
Destruction of VISTA by TRIM25 ablation in T cells potentiates cancer immunotherapy
PRJNA1183363 | ENA
OtherExogenous RNA surveillance by proton-sensing TRIM25
Exogenous mRNAs require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens with in vitro-transcribed mRNAs in lipid nanoparticles (LNPs). Heparan sulfate proteoglycans and vacuolar ATPase wer...
ORGANISM(S): Homo sapiens 
2025-04-04 | GSE264535 | GEO
UnknownTRIM25 targets p300 for degradation.
Not available
S-EPMC10539465 | biostudies-literature
GenomicsRNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination
RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination
PRJNA414217 | ENA
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