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MetabolomicsOrnithine Decarboxylase in Gastric Epithelial Cells Promotes the Immunopathogenesis of Helicobacter pylori Infection

Colonization by H. pylori is associated with a wide range of gastric diseases, ranging from superficial gastritis to more severe pathologies, including intestinal metaplasia and adenocarcinoma. The interplay of the host response and the pathogen affect the outcome of disease. One major component ...

2022-06-15 | MTBLS3235 | MetaboLights
MetabolomicsEnhanced fatty acid synthesis by Sigma28 in stringent responses contributes to multidrug resistance and biofilm formation in Helicobacter pylori

The metabolism of bacteria is closely associated with antibiotic resistance, yet the role of metabolism in the resistance of Helicobacter pylori remains unclear. In this study, we conducted integrated analysis using transcriptomics and non-targeted metabolomics to investigate the metabolic change...

2024-06-26 | MTBLS9981 | MetaboLights
ProteomicsIdentification of Helicobacter pylori LolD
We engineered a derivative of H. pylori strain 26695 that expresses an N-terminal DDK-tagged version of LolF from the endogenous locus. As controls, we also engineered strains to express DDK-tagged versions of two unrelated inner membrane proteins ExbD2 and FrdC. The tagged proteins were affinity pu...
ORGANISM(S): Helicobacter Pylori 26695 (ncbitaxon:85962) 
2023-01-31 | MSV000091176 | MassIVE
GenomicsChIP-seq of Helicobacter pylori N6 wild-type and HP1021 deletion mutant under microaerophilic and aerobic conditions (optimal growth and oxidative stress conditions, respectively).
We performed DNA-protein interaction (ChIP-seq) analyses for Helicobacter pylori N6 wild-type (WT) and HP1021 deletion mutant (ΔHP1021::aphA-3) under oxidative stress (21% O2) and optimal microaerobic growth (5% O2) conditions. We detected 100 binding sites of HP1021 on the H. pylori N6 chromosome, ...
ORGANISM(S): Helicobacter pylori 
2023-09-23 | E-MTAB-13026 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Helicobacter pylori N6 wild-type and HP1021 deletion mutant under microaerophilic and aerobic conditions (optimal growth and oxidative stress conditions, respectively)
We performed transcriptome (RNA-seq) analyses for Helicobacter pylori N6 wild-type (WT) and HP1021 deletion mutant (ΔHP1021::aphA-3) under oxidative stress and optimal microaerobic growth conditions. The expression of 411 genes was affected by oxidative stress in stressed wild-type cells (WTS) comp...
ORGANISM(S): Helicobacter pylori 
2023-09-23 | E-MTAB-13025 | biostudies-arrayexpress
TranscriptomicsExpression data from Helicobacter pylori isolates infecting a gastric epithelial progenitor cell line
Helicobacter pylori clinical isolates can establish themselves in gastric epithelial stem cells and this interaction may have implications for gastric tumorigenesis. Mouse gastric epithelial progenitor cells (mGEPs) were infected for 24hrs with Helicobacter pylori clinical isolates Kx1 and Kx2. Kx1 ...
ORGANISM(S): Helicobacter pylori 
2010-05-26 | E-GEOD-10261 | biostudies-arrayexpress
ProteomicsComparative proteomics of Helicobacter pylori strains reveals geographical features rather than genomic variations
Helicobacter pylori, which is known as pathogens of various gastric diseases, have many types of genome sequence variants. That is part of the reason why pathogenesis and infection mechanisms of the H. pylori-driven gastric diseases have not been well clarified yet. Here we performed a large-scale p...
ORGANISM(S): Helicobacter Pylori F16 Helicobacter Pylori F30 Helicobacter Pylori Helicobacter Pylori Ok113 Helicobacter Pylori Ok310 Helicobacter Pylori F32 
2018-12-28 | PXD011364 | JPOST Repository
TranscriptomicsGenetic diversity among Helicobacter pylori strains
Helicobacter pylori colonizes the stomach of half of the world's population, causing a wide spectrum of disease ranging from asymptomatic gastritis to ulcers to gastric cancer. Although the basis for these diverse clinical outcomes is not understood, more severe disease is associated with strains ha...
ORGANISM(S): Helicobacter pylori 
2001-07-25 | E-GEOD-6 | biostudies-arrayexpress
ProteomicsThe proteins identified from Helicobacter pylori strain Tx30a-derived extracellular vesicles (HpEVs-Tx30a)
Helicobacter pylori strain ATCC51932 (Tx30a) was suspended in Brucella broth supplemented with 5% depleted exosomes FCS. The initial optical density at 600 nm of the bacterial suspension was adjusted to 0.02 in 200 mL of Brucella broth + 0.5% depleted exosome FCS. H. pylori was grown in a 500 mL fla...
ORGANISM(S): Helicobacter Pylori 
2025-03-17 | PXD056530 | JPOST Repository
ProteomicsThe proteins identified from Helicobacter pylori strain TN2wt-derived extracellular vesicle (HpEV-TN2wt)
Helicobacter pylori strain TN2wt was suspended in Brucella broth supplemented with 5% depleted exosomes FCS. The initial optical density at 600 nm of the bacterial suspension was adjusted to 0.02 in 200 mL of Brucella broth + 0.5% depleted exosome FCS. H. pylori was grown in a 500 mL flask under mic...
ORGANISM(S): Helicobacter Pylori 
2025-03-17 | PXD056531 | JPOST Repository
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