Sort   by:  
 Page size 
ModelsCD4 T cell signaling
Caveolin-1 (CAV1) is a vital scaffold protein heterogeneously expressed in both healthy and malignant tissue. We focus on the role of CAV1 when overexpressed in T-cell leukemia. Previously, we have shown that CAV1 is involved in cell-to-cell communication, cellular proliferation, and immune synapse ...
3521 | Cell Collective
ModelsT Cell Receptor Signaling
Cellular decisions are determined by complex molecular interaction networks. Large-scale signaling networks are currently being reconstructed, but the kinetic parameters and quantitative data that would allow for dynamic modeling are still scarce. Therefore, computational studies based upon the stru...
2171 | Cell Collective
ModelsPuniya2021 - Naive CD4+ T cell metabolic model
CD4+ T cells are critical components in the human immune system. They produce cytokines to fight against pathogens and abnormal cells and stimulate other cells, such as B cells, macrophages, and neutrophils, to generate an immune response. Naive CD4+ T cells are precursor cells that can differentia...
2023-11-27 | MODEL1909260003 | BioModels
FROG 
MetabolomicsChanges in lipid profiles of epileptic mouse model

INTRODUCTION: Approximately 1% of the world's population is impacted by epilepsy, a chronic neurological disorder characterized by seizures. One-third of epileptic patients are resistant to AEDs, or have medically refractory epilepsy (MRE). One non-invasive treatment that exists...

2022-01-06 | MTBLS1432 | MetaboLights
ModelsHIV-1 interactions with T Cell Signalling Pathway
Motivation: Human immunodeficiency virus type 1 (HIV-1) hijacks host cellular processes to replicate within its host. Through interactions with host proteins, it perturbs and interrupts signaling pathways that alter key cellular functions. Although networks of viralhost interactions have been relati...
2738 | Cell Collective
ModelsDifferentiation of T lymphocytes
There is a vast amount of molecular information regarding the differentiation of T lymphocytes, in particular regarding in vitro experimental treatments that modify their differentiation process. This publicly available information was used to infer the regulatory network that controls the different...
2215 | Cell Collective
ModelsT-LGL Survival Network 2011
The blood cancer T cell large granular lymphocyte (T-LGL) leukemia is a chronic disease characterized by a clonal proliferation of cytotoxic T cells. As no curative therapy is yet known for this disease, identification of potential therapeutic targets is of immense importance. In this paper, we perf...
2407 | Cell Collective
UnknownA Mechanistic Computational Model Reveals That Plasticity of CD4+ T Cell Differentiation Is a Function of Cytokine Composition and Dosage.
Not available
S-EPMC6083813 | biostudies-literature
ModelsT-LGL Survival Network 2008
T cell large granular lymphocyte (T-LGL) leukemia features a clonal expansion of antigen-primed, competent, cytotoxic T lymphocytes (CTL). To systematically understand signaling components that determine the survival of CTL in T-LGL leukemia, we constructed a T-LGL survival signaling network by inte...
2176 | Cell Collective
UnknownIntegrative computational approach identifies drug targets in CD4+ T-cell-mediated immune disorders.
Not available
S-EPMC7822845 | biostudies-literature
Sort   by:  
 Page size