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TranscriptomicsTranscription profiling of three human multiple myeloma cell lines treated with 5-aza-2-deoxycytidine and/or trichostatin A
To identify epigenetically silenced genes in multiple myeloma (MM) cell lines and to determine the effects of 5-aza-2-deoxycytidine and trichostatin A on gene expression. We treated 3 multiple myeloma cell lines (MM1, NCI-H929, U266) with 5-aza-2-deoxycytidine and/or trichostatin A.
ORGANISM(S): Homo sapiens 
2008-02-01 | E-MEXP-1269 | biostudies-arrayexpress
TranscriptomicsGenome-wide microRNA expression profiling identifies miR-9-3 and miR-193a as targets for DNA methylation in non-small cell lung cancers
Purpose: The major aim of this study was to investigate the role of DNA methylation (referred to as methylation) on microRNA (miRNA) silencing in non-small cell lung cancers (NSCLC). Experimental Design: We performed microarray expression analyses of 856 miRNAs in NSCLC A549 cells before and after t...
ORGANISM(S): Homo sapiens 
2012-03-13 | E-GEOD-31579 | biostudies-arrayexpress
TranscriptomicsGENOME-WIDE CpG ISLAND METHYLATION ANALYSIS IN NON-SMALL CELL LUNG CANCER PATIENTS [Affymetrix expression data]
Epigenetic changes largely contribute to the regulation of gene expression in cancer cells. DNA methylation is part of the epigenetic gene regulation complex which is relevant for the pathogenesis of cancer. We performed a genome-wide search for methylated CpG islands in tumors and corresponding non...
ORGANISM(S): Homo sapiens 
2012-11-26 | E-GEOD-32496 | biostudies-arrayexpress
TranscriptomicsEVI1 promotes tumor growth via transcriptional repression of MS4A3
Background: The transcription factor EVI1 regulates cellular proliferation, differentiation, and apoptosis, and contributes to an aggressive course of disease in myeloid leukemias and other malignancies. Notwithstanding, knowledge about the target genes mediating its biological and pathological func...
ORGANISM(S): Homo sapiens 
2015-08-30 | E-GEOD-60100 | biostudies-arrayexpress
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