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ProteomicsCyclotides isolated from violet plants of Cameroon are inhibitors of human prolyl oligopeptidase
Traditional medicine and the use of herbal remedies are well established in the African health care system. For instance, Violaceae plants are used for antimicrobial or anti-inflammatory applications in folk medicine. This study describes the phytochemical analysis and bioactivity screening of four ...
ORGANISM(S): Allexis 
2021-08-09 | PXD026664 | Pride
Prolyl oligopeptidase (pop) Protease inhibitor Allexis cauliflora Peptide Cyclic cystine-rich peptides 
ProteomicsChemical proteomics to elucidate target proteins of cysteine-stabilized and circular peptides
Cyclotides are circular and cystine-rich peptides which are little amenable to chemical modifications for probe design in chemical biology. The cyclotide [T20K]kalata B1 is an immune system modulating drug reported for its therapeutic application in multiple sclerosis.
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2017-09-26 | PXD004798 | Pride
Peptide drug Target deconvolution Cyclotides Multiple sclerosis Target identification 
ProteomicsPeptidomics of circular cysteine-rich plant peptides – Analysis of the diversity of cyclotides from Viola tricolor by transcriptome- and proteome-mining
circular peptides, cystine-knot, transcriptome, peptidomics, Violaceae, ribosomally synthesized and post-translationally modified peptides natural products, mass spectrometry, 1kp
ORGANISM(S): Viola tricolor Viola tricolor subsp. tricolor 
2015-10-02 | PXD002867 | Pride
Peptidomics Ribosomally synthesized and post-translationally modified peptides natural products Transcriptome Mass spectrometry Cystine-knot 1kp Circular peptides Violaceae 
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