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TranscriptomicsHuman resistin alters lung mRNA expression from helminth-infected lungs.
Goal: To examine the effects of human resistin during helminth infection. Methodology: To examine the function of human resistin (hResistin), we utilized transgenic mice expressing the human resistin gene along with its entire regulatory region (hRetnTg+). Following infection with the helminth Nippo...
ORGANISM(S): Mus musculus 
2014-11-14 | E-GEOD-60537 | biostudies-arrayexpress
TranscriptomicsHelminth Infection Reactivates Latent γ-herpesvirus Via Cytokine Competition at a Viral Promoter
Mammals are co-infected by multiple pathogens that interact through unknown mechanisms. We found that helminth infection, characterized by the induction of the cytokine interleukin-4 (IL-4) and the activation of the transcription factor Stat6, reactivated murine gammaherpesvirus infection in vivo. I...
ORGANISM(S): Mus musculus 
2014-06-26 | E-GEOD-58116 | biostudies-arrayexpress
TranscriptomicsPRONOUNCED PHENOTYPE IN ACTIVATED TREG CELLS DURING A CHRONIC HELMINTH INFECTION
Although several markers have been associated with the characterization of regulatory T cells (Treg) and their function, no studies have investigated the dynamics of their phenotype during infection. Since the necessity of Treg to control immunopathology has been demonstrated, we used the chronic he...
ORGANISM(S): Mus musculus 
2010-04-12 | E-GEOD-17580 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lungs from SCID and wild type mice infected with L3 stage infectious Nippostrongylus brasiliensis to examine the innate immune response to helminth infection in the lung.
The goal of this experiment was to examine the innate immune response to helminth infection in the lung. Hookworms (like many other helminths) use an obligate migration pathway through the lung. Their infection has been characterized in the gut in detail, but early immune responses in the lung have ...
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-3414 | biostudies-arrayexpress
Transcriptomicsmicroarray analysis of bone marrow derived macrophages stimulated with helminth larvae and immune serum
Mouse bone marrow derived macrophages were stimulated with L3 larvae of the helminth Heligmosomoides polygyrus (Hp) (500 L3 /1 mio cells) in the presence or absence of immune serum (1:50 v:v) from challenge-Hp-infected mice.
ORGANISM(S): Mus musculus 
2013-12-31 | E-MEXP-3920 | biostudies-arrayexpress
MetabolomicsEpithelial-Cell-Derived Phospholipase A2 Group 1B Is an Endogenous Anthelmintic
Immunity to intestinal helminth infections has been well studied, but the mechanism of helminth killing prior to expulsion remains unclear. Here we identify epithelial-cell-derived phospholipase A2 group 1B (PLA2g1B) as a host-derived endogenous anthelmintic. PLA2g1B is elevated in resistant mice an...
2018-08-13 | MTBLS523 | MetaboLights
Genomics50 Helminth Genomes Initiative
50 Helminth Genomes Initiative
PRJEB2679 | ENA
UnknownPre-existing helminth infection impairs the efficacy of adjuvanted influenza vaccination in mice.
Not available
S-EPMC8970517 | biostudies-literature
GenomicsAlox15 restrains glycolysis to support M2 macrophage effector function during helminth immunity.
Alox15 restrains glycolysis to support M2 macrophage effector function during helminth immunity.
PRJNA1510659 | ENA
UnknownIL-11 acts as an alarmin-like pro-inflammatory mediator regulating mucosal responses during helminth infection.
Not available
S-EPMC12917958 | biostudies-literature
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