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TranscriptomicsU2AF1 mutations alter splice site recognition in hematological malignancies
Whole-exome sequencing studies have identified common mutations affecting genes encoding components of the RNA splicing machinery in hematological malignancies. Here, we sought to determine how mutations affecting the 3' splice site recognition factor U2AF1 altered its normal role in RNA splicing. W...
ORGANISM(S): Homo sapiens 
2014-09-23 | E-GEOD-58871 | biostudies-arrayexpress
ProteomicsDiscovery of novel CRBN ligands by virtual screening and biological evaluation against multiple hematological cancer cell lines
Immunomodulatory drugs, functioning as cereblon (CRBN) E3 ligase ligands, have been approved for treating various hematological malignancies by hijacking the function of CRBN E3 ligase and inducing the degradation of multiple CRBN-associated substrates. However, the inevitable emergence of drug resi...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD061290 | Pride
Hematological cancer  imids  crbn ligands  molecular docking  antitumor evaluation 
ProteomicsNovel molecular glue degraders against broad range of myeloma and lymphoma cancer cell lines
Targeted protein degradation of neosubstrates plays a crucial role in treating hematological cancers with IMiDs therapy. However, the inevitable drug resistance and hematological toxicities remain persistent challenges, limiting their clinical efficacy. Herein, we present the discovery of a lead deg...
ORGANISM(S): Homo Sapiens 
2024-06-22 | PXD053334 |
TranscriptomicsDysregulated expression of genes in regulatory T cells from metastatic castration-resistant prostate cancer patients
We analyzed the global gene expression pattern of Tregs between healthy donors and prostate cancer patients. We found that genes related to cell cycle, cellular proliferation, immune responses, hematological system development and function were differentially expressed in Tregs from prostate cancer...
ORGANISM(S): Homo sapiens 
2013-03-05 | E-GEOD-38043 | biostudies-arrayexpress
UnknownFinancial toxicity in hematological malignancies: a systematic review.
Not available
S-EPMC9033803 | biostudies-literature
GenomicsComprehensive genetic analysis of Epstein-Barr virus-associated hematological malignancy
Comprehensive genetic analyses including whole-exome sequencing, targeted sequencing, and whole-genome sequencing of the human genome and the Epstein-Barr virus (EBV) genome were performed to reveal the molecular pathogenesis of EBV-associated hematological malignancy.
EGAS00001003159 | EGA
UnknownDetection of Hematological Malignancies Using N-NOSE (Nematode-NOSE).
Not available
S-EPMC11954616 | biostudies-literature
GenomicsDiscovery of a paralog-selective p300 protein degrader with potent anti-cancer activity in hematological malignancies
Discovery of a paralog-selective p300 protein degrader with potent anti-cancer activity in hematological malignancies
PRJNA1284952 | ENA
UnknownThe Role of RNA-Binding Proteins in Hematological Malignancies.
Not available
S-EPMC9455611 | biostudies-literature
GenomicsA DNA methylation database of human and mouse hematological malignancy cell lines
A DNA methylation database of human and mouse hematological malignancy cell lines
PRJNA1126749 | ENA
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