Hematological malignancies

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Organisms

Homo sapiens (350)
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Aerococcus urinae NBRC 15544 = CCUG 36881 (17)
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Organisms

Homo sapiens (229)
Mus musculus (102)
Danio rerio (3)
Canis lupus familiaris (2)
human gammaherpesvirus 4 (1)
Klebsiella pneumoniae (1)
Homo sapiens/Mus musculus xenograft (1)
synthetic construct (1)
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Caenorhabditis elegans (1)
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Tissue

Cell culture (5)
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Disease

Burkitt Lymphoma (2)
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Instrument Platform

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2006 (1)

UNIPROT ID/AC

A0A024R8H9 (1)
A0A024RC46 (1)
A0A075B6P5 (1)
A0A087WTX5 (1)
A0A087WWK8 (1)
A0A087WYL9 (1)
A0A087X130 (1)
A0A087X1V9 (1)
A0A0A0MR66 (1)
A0A0A0MSA7 (1)
A0A0C4DG89 (1)
A0A0C4DGT3 (1)
A0AVK6 (1)
A0FGR8 (1)
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A2IPI2 (1)
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A6NHL2 (1)
A6NHR9 (1)
A6NJJ0 (1)
A6NNZ2 (1)
A8CG34 (1)
A8MPP1 (1)
A8MUU1 (1)
A9IYQ1 (1)
B2RPK0 (1)

CHEBI ID

CHEBI:16927 (3)
CHEBI:17752 (3)
CHEBI:30918 (3)
CHEBI:30816 (3)
CHEBI:16610 (3)
CHEBI:28971 (3)
CHEBI:17650 (3)
CHEBI:28834 (3)
CHEBI:36274 (3)
CHEBI:28790 (3)
CHEBI:22470 (3)
CHEBI:90 (3)
CHEBI:15318 (3)
CHEBI:17256 (3)
CHEBI:27823 (3)
CHEBI:17562 (3)
CHEBI:27373 (3)
CHEBI:24813 (3)
CHEBI:10072 (3)
CHEBI:16708 (3)
CHEBI:16450 (3)
CHEBI:16704 (3)
CHEBI:28997 (3)
CHEBI:17533 (3)
CHEBI:18107 (3)
CHEBI:28865 (3)
CHEBI:16914 (3)
CHEBI:17368 (3)
CHEBI:17687 (3)
CHEBI:30769 (3)

Metabolite Name

Difloxacin (3)
3'-AMP (3)
1-Methylnicotinamide (3)
Betaine (3)
5-Methylcytosine (3)
2-Isopropylmalic acid (3)
L-Arginine (3)
Theobromine (3)
Pantothenic acid (3)
L-Glutamine (3)
Xanthosine (3)
Cytidine (3)
Xanthine (3)
Creatinine (3)
Hypoxanthine (3)
Carbazole (2)
N-Acetyl-L-arginine (2)
Folic acid (2)
21-Deoxycortisol (2)
Acetanilide (2)
Sakuranetin (2)
4-Hydroxyquinoline (2)
Thiamphenicol (2)
N-acetylglucosaminylasparagine (2)
Lauramidopropylbetaine (2)
Indole-3-pyruvic acid (2)
Histidine (2)
Dyphylline (2)
3-Methylindole (2)
Phenylephrine (2)

First Public Date

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2014 (36)
2019 (22)
2020 (18)
2018 (18)
2017 (16)
2015 (14)
2016 (8)
2013 (4)

Modelling Approach

Ordinary differential equation model (2)

Study status

Completed (2)
Not provided (1)
Recruiting (1)

Lab affiliation

Indiana University School of Medicine (2)
1Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA. 2Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA. 3Biological and Biomedical Sciences Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. (1)
Associate Member, Hematological Malignancies Program St. Jude Children's Research Hospital Memphis-TN UA (1)
Beijing Institute of Pharmacology and Toxicology (1)
Cambridge University (1)
Cell Signalling (1)
Center for Translational Research in Hematological Malignancies, Houston Methodist Neal Cancer Center, Houston Methodist Academic Institute (1)
Chemistry Department, Scripps Research (1)
Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany (1)
Committee on Cancer Biology, The University of Chicago, Chicago, IL, USA Department of Pathology, The University of Chicago, Chicago, IL, USA Department of Pediatrics, The University of Chicago, Chicago, IL, USA The University of Chicago Medicine Comprehensive Cancer Center, University of Chicago, Chicago, IL, USA (1)
Division of Blood Cells and Blood Cancer The Walter and Eliza Hall Institute of Medical Research 1G Royal Parade, Parkville Victoria, Australia, 3050 (1)
Immunology Department, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland (1)
Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA (1)
Molecular Proteomics Laboratory, Biomedical Research Center (BMFZ), Heinrich-Heine-University, Düsseldorf, Germany (1)
Proteomics Lab, National Centre for Cell Science, Pune, Maharashtra, India (1)
UC Proteomics Laboratory, Department of Cancer Biology, University of Cincinnati, Cincinnati, Ohio 45267 USA (1)

Keyword

Cyclosporine (2)
Cyclosporins (2)
UFUR (1)
Thalidomide (1)
Tacrolimus (1)
Methotrexate (1)
Busulfan (1)
Fludarabine (1)
Fludarabine phosphate (1)
Vorinostat (1)
Cyclophosphamide (1)
Oxaliplatin (1)

IsPrivate

False (2)

Classification

viruses (1)
bacteria (1)

Study type

Transcription profiling by array (65)
RNA-seq of coding RNA (18)
ChIP-seq (11)
Comparative genomic hybridization by array (8)
DNA-seq (5)
RNA-seq of coding RNA from single cells (3)
Interventional (3)
CUT&TAG (1)
Unknown experiment type (1)
Animal - One-color microarray (1)
Spatial transcriptomics by high-throughput sequencing (1)
Methylation profiling by array (1)
Methylation profiling by high throughput sequencing (1)
Observational (1)

Release Date

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2020 (243)
2019 (208)
2018 (162)
2016 (123)
2017 (121)
2015 (115)
2014 (79)
2013 (55)
2026 (45)
2011 (36)
2012 (31)
2010 (24)
2009 (18)
2008 (15)
2007 (6)
2006 (2)
2004 (1)
2005 (1)
2002 (1)

Location

United States (2)
India (1)
Taiwan (1)

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U2AF1 mutations alter splice site recognition in hematological malignancies

Whole-exome sequencing studies have identified common mutations affecting genes encoding components of the RNA splicing machinery in hematological malignancies. Here, we sought to determine how mutations affecting the 3' splice site recognition factor U2AF1 altered its normal role in RNA splicing. W...

ORGANISM(S): Homo sapiens

2014-09-23 | E-GEOD-58871 | biostudies-arrayexpress

The Role of RNA-Binding Proteins in Hematological Malignancies.

Not available

S-EPMC9455611 | biostudies-literature

Financial toxicity in hematological malignancies: a systematic review.

Not available

S-EPMC9033803 | biostudies-literature

Defective RNA helicase genes underlie predisposition to colorectal and hematological malignancies

PRJNA952511 | ENA

Antibiotics treatment ameliorates TET2 loss-of-function associated hematological malignancies

PRJNA533092 | ENA