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MetabolomicsSCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we used domain-focused CRISPR screening to identify the nuclear phosphatase SCP4 as a dependency in AML, yet this enzyme is dispensable in normal hematopoietic progenitor cells. Usi...
2025-05-29 | MTBLS3707 | MetaboLights
MetabolomicsCholesterol dysregulation contributes to hematopoietic failure in parn-mutant zebrafish with implications for dyskeratosis congenita
Germline mutations in PARN cause dyskeratosis congenita (DC), an inherited bone marrow failure syndrome characterized by multilineage cytopenia and progression to myeloid disease. The mechanisms underlying this malignant transformation have not been fully elucidated. Here we show, using a loss-of-fu...
2026-09-29 | MTBLS15863 | MetaboLights
GenomicsHistone Demethylase Lsd1 is Required to Repress Hematopoietic Stem and Progenitor Cell Signatures During Blood Cell Maturation
Here we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on LysM-bM-^@M-^I4 or LysM-bM-^@M-^I9 (H3K4/K9), is an indispensible epigenetic governor of hematopoietic differentiation. Integrative genomic analysis in primary hematopoietic cells, combining global occ...
ORGANISM(S): Mus musculus 
2013-06-25 | E-GEOD-40440 | biostudies-arrayexpress
ProteomicsDecoding the signalling profile of hematopoietic progenitor kinase 1 (HPK1) in innate immunity: a proteomic approach
The fine-tuned spatiotemporal response of leukocytes to external stimuli is a hallmark of the immune system. Sensing of stimuli occurs through cell surface receptors, which transmit signals into the cell. Signaling via β2 integrins, B cell, and T cell receptors involve similar pathways. However, the...
ORGANISM(S): Homo sapiens (Human) 
2022-02-10 | PXD021136 | Pride
Hematopoietic progenitor kinase 1  interactome  innate immunity  neutrophils 
TranscriptomicsTranscriptional landscape, long non-coding RNAs and post-transcriptional regulation in hematopoietic stem/progenitor cell differentiation
Hematopoietic stem cells (HSC) possess life-long self-renewal activity and generate a series of multipotent progenitors that differentiate into lineage-committed progenitors and subsequently mature cells. Recently, functionally distinct stem and progenitor cell types have been identified, however, a...
ORGANISM(S): Mus musculus 
2014-10-08 | E-MTAB-1963 | biostudies-arrayexpress
TranscriptomicsDownstream Targets of HOXB4 in the primitive hematopoietic progenitor EML Cell line
Enforced expression of the homeobox transcription factor HOXB4 has been shown to enhance hematopoietic stem cell (HSC) self-renewal and expansion ex vivo and in vivo. In order to investigate the largely unknown downstream targets of HOXB4 in hematopoietic progenitor cells, HOXB4 was constitutively ...
ORGANISM(S): Mus musculus 
2010-04-20 | E-GEOD-20604 | biostudies-arrayexpress
TranscriptomicsDirect contact with mesenchymal stromal cells impacts CD133+ hematopoietic stem cells during ex-vivo expansion
Direct contact with mesenchymal stromal impacts on migratory behavior and gene expression profile of CD133+ hematopoietic stem cells during ex-vivo expansion Objective: To investigate the impact of direct contact between mesenchymal stromal cells (MSCs) and CD133+ hematopoietic stem cells (HSCs) in ...
ORGANISM(S): Homo sapiens 
2008-11-12 | E-GEOD-13566 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of adherent and non-adherent human hematopoietic progenitor cells
Comparison of gene expression of the adherent and non-adherent fraction of hematopoietic progenitor cells.
ORGANISM(S): Homo sapiens 
2007-03-13 | E-MEXP-586 | biostudies-arrayexpress
TranscriptomicsExpression data for conditional Dnmt1knockout hematopoietic stem and progenitor cells
DNA methylation is essential for mammalian development and plays crucial roles in a variety of biological processes. The DNA methyltransferase Dnmt1 serves to maintain parental cell methylation patterns on daughter DNA strands in mitotic cells, however, the precise role of Dnmt1 in regulation of qui...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-15840 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse adult bone marrow cells reveals candidate genes form expansion and transformation of hematopoietic stem cells by NUP98-HOX Fusion Genes
BACKGROUND: Hox genes are implicated in hematopoietic stem cell (HSC) regulation as well as in leukemia development through translocation with the nucleoporin gene NUP98. Interestingly, an engineered NUP98-HOXA10 (NA10) fusion can induce a several hundred-fold expansion of HSCs in vitro and NA10 and...
ORGANISM(S): Mus musculus 
2008-06-17 | E-GEOD-9079 | biostudies-arrayexpress
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