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ProteomicsOxidative Stress and Metabolic Plasticity of NOX-2 KO mice Hematopoitic Stem Cells Homeostasis Proteomics Profile
We investigated the contribution of NOX-2 to redox balance, mitochondrial respiration, and glycolytic compensation in lineage-negative Sca-1⁺c-Kit⁺ (SKL) bone marrow stem cells from wild-type (WT) and NOX-2 knockout (NOX2-KO) mice. Proteomic profiling identified differentially expressed proteins inv...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-03 | PXD066664 | Pride
Hematopoitic stem cells Nox-2 ko Nox-2 Proteomics Metabolic plasticity 
TranscriptomicsUnravelling the heterogeneity of haemogenic endothelium in human pluripotent stem cell differentiation cultures
In embryo, few Endothelial cells from Aorta would be producing Haemogenic endothelium (HE) cells. These HE cells would then be progressing to take kind of a round shape and Undergo EHT. They then take a full round shape to make Intra-aortic haematopoietic clusters (IAHC) cells. These IAHC cells woul...
ORGANISM(S): Homo sapiens 
2020-05-02 | E-MTAB-8271 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing of p53 KO and Utx/p53 DKO Hematopoietic Stem Cells Transcriptomes
Hematopoitic stem cells from Utx/p53 DKO mice showed increased self-renewal potential and predisposition of differentiation to myeloid lineage compared with those from p53 KO mice. To figure out what mechanism leads to the increased self-renewal, we compared the transcriptional profiles using RNA-se...
ORGANISM(S): Mus musculus 
2018-10-08 | GSE97737 | GEO
GenomicsUnravelling the heterogeneity of haemogenic endothelium in human pluripotent stem cell differentiation cultures
Unravelling the heterogeneity of haemogenic endothelium in human pluripotent stem cell differentiation cultures
PRJEB34313 | ENA
GenomicsMus musculus
Next Generation Sequencing of p53 KO and Utx/p53 DKO Hematopoietic Stem Cells Transcriptomes
PRJNA382783 | ENA
TranscriptomicsMicroarray analysis of IdHP cells compared to LKS, Control ProB and E2A-/- progenitors
Self-renewal potential and multipotency are hallmarks of the stem cell1-3. It is generally conceived that acquisition of such a stemness requires rejuvenation of somatic cells through reprogramming of genetic and epigenetic status. We show here that a simple blockage of cell differentiation is suffi...
ORGANISM(S): Mus musculus 
2014-06-01 | E-GEOD-46158 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of IdHP cells compared to LKS, Control ProB and E2A-/- progenitors
Self-renewal potential and multipotency are hallmarks of the stem cell1-3. It is generally conceived that acquisition of such a stemness requires rejuvenation of somatic cells through reprogramming of genetic and epigenetic status. We show here that a simple blockage of cell differentiation is suffi...
ORGANISM(S): Mus musculus 
2014-06-01 | GSE46158 | GEO
GenomicsStudy on the mechanism of TSC22D3 regulating the stability of P53 to promote the quiescence of hematopoietic stem cells
Study on the mechanism of TSC22D3 regulating the stability of P53 to promote the quiescence of hematopoietic stem cells
PRJNA742366 | ENA
TranscriptomicsMicroRNA expression during Hematopoiesis
Murine ES cells were grown on confluent OP-9 and differentiated along the hematopoitic lineage. To assess the effects of Notch in hematopoiesis, activated Notch was overexpressed from Day 5 to Day 8. Samples included Day 5 (control) and Day 8 Notch On and Day 8 Notch Off, the samples were done in tr...
ORGANISM(S): Mus musculus 
2011-04-03 | E-GEOD-28338 | biostudies-arrayexpress
GenomicsMus musculus
Microarray analysis of IdHP cells compared to LKS, Control ProB and E2A-/- progenitors
PRJNA197388 | ENA
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