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GenomicsFgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of Trophoblast Stem Cells
Derivation and maintenance of TS cells depends on the presence of Fgf signalling. Numerous gene knock-out experiments identified the mitogen activated kinase Mek/Erk branch of the Fgf signalling pathway as predominantly active in both TS cells and extraembryonic ectoderm. Therefore, we tested change...
ORGANISM(S): Mus musculus 
2015-08-18 | E-MTAB-3565 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation to determine DNA methylation of mouse pluripotent and differentiated tissues
ChIP-on-chip analysis using a methylation specific antibody was performed on a series of pluripotent and differentiated tissues.
ORGANISM(S): Mus musculus 
2008-06-27 | E-TABM-476 | biostudies-arrayexpress
TranscriptomicsPromoter Capture Hi-C of mouse ESC and TSC
Chromatin organisation of trophoblast stem cells (TSC) were compared with that of embryonic stem cells (ESC). The method enriches Hi-C libraries, to detect promoter interactions at restriction fragment level. We prepared Hi-C libraries from TSC and ESC (serum grown) samples and enriched them with a ...
ORGANISM(S): Mus musculus 
2018-09-05 | E-MTAB-6585 | biostudies-arrayexpress
GenomicsEpigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast [MeDIP-Seq]
Reprogramming of ES cells towards the trophoblast lineage, and specifally into self-renewing TS cells, can seemingly be achieved by manipulation of transcription factors such as Cdx2 and Oct4, or modulation of signalling cascades, notably Ras signalling. Here we analyze the arising cells from such t...
ORGANISM(S): Mus musculus 
2014-11-24 | E-GEOD-62138 | biostudies-arrayexpress
TranscriptomicsEpigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast [RNA-Seq]
Reprogramming of ES cells towards the trophoblast lineage, and specifally into self-renewing TS cells, can seemingly be achieved by manipulation of transcription factors such as Cdx2 and Oct4, or modulation of signalling cascades, notably Ras signalling. Here we analyze the arising cells from such t...
ORGANISM(S): Mus musculus 
2014-11-24 | E-GEOD-62149 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profile of human placenta derived trophoblast organoid cultures with its tissue of origin, human placental villi.
The aim of this microarray experiment was to compare the overall transcriptomic profile of human placenta derived trophoblast organoid cultures with its tissue of origin, human placental villi. As the placental villi contains both trophoblast and stromal populations, we have included placenta derive...
ORGANISM(S): Homo sapiens 
2018-11-28 | E-MTAB-6683 | biostudies-arrayexpress
GenomicsMaternal DNA methylation regulates early trophoblast development
Critical roles for DNA methylation in embryonic development are well established, but less is known about the roles of DNA methylation during trophoblast development, the extraembryonic lineage that gives rise to the placenta. Here we dissected the role of DNA methylation in trophoblast development ...
ORGANISM(S): Mus musculus 
2016-01-07 | E-GEOD-66049 | biostudies-arrayexpress
TranscriptomicsWhole embryo RNA-seq of 73 mouse mutant lines and baseline controls from the Mouse Genetics Project (DMDD)
The Deciphering the Mechanisms of Developmental Disorders (DMDD) programme analyses the morphological and molecular phenotypes of embryonic and perinatal lethal mouse mutant lines. Here we show that single whole embryo RNA-seq of 73 mouse mutant lines (>1000 transcriptomes) uncovers transcriptional ...
ORGANISM(S): Mus musculus 
2019-10-31 | E-MTAB-7322 | biostudies-arrayexpress
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