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ProteomicsStage-Specific Proteomic Adaptations to Heme-Induced Oxidative Stress in Aedes aegypti: Differential Mechanisms in Larvae and Adults
This dataset derives from a comparative quantitative proteomics study designed to elucidate stage-specific molecular responses to heme-induced oxidative stress in Aedes aegypti, a major vector of dengue, Zika, and chikungunya viruses. During blood digestion in hematophagous insects, the release of f...
ORGANISM(S): Aedes aegypti 
2026-02-02 | PXD072226 | Pride
Heme toxicity  oxidative stress  detoxification enzymes 
GenomicsDimethyl fumarate increases fetal hemoglobin, provides heme detoxification, and corrects anemia in sickle cell disease
Dimethyl fumarate increases fetal hemoglobin, provides heme detoxification, and corrects anemia in sickle cell disease
PRJNA414450 | ENA
TranscriptomicsTranscription profiling of C. elegans reveals heme homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins
Hemes are essential but potentially cytotoxic cofactors that participate in critical and diverse biological processes. Although the pathway and intermediates for heme biosynthesis have been well defined, the intracellular networks which mediate heme trafficking remain unknown. Caenorhabditis e...
ORGANISM(S): Caenorhabditis elegans 
2008-10-18 | E-GEOD-8696 | biostudies-arrayexpress
UnknownHemozoin: a waste product after heme detoxification?
Not available
S-EPMC11881329 | biostudies-literature
TranscriptomicsTranscription profiling of Aedes aegypti treated with permethrin to identify detoxification genes
Genomic analysis of detoxification genes in the mosquito Aedes aegypti.
ORGANISM(S): Aedes aegypti 
2008-02-09 | E-TABM-413 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of insecticide susceptible and resistant strains of Aedes aegypti to identify detoxification genes
Genomic analysis of detoxification genes in the mosquito Aedes aegypti
ORGANISM(S): Aedes aegypti 
2008-02-09 | E-TABM-414 | biostudies-arrayexpress
ProteomicsHigh Heme Resistance in Serratia plymuthica: Adaptive Mechanisms and Possible Role in Aedes aegypti Midgut Homeostasis
Mosquitoes of the genus Aedes are primary vectors of arboviruses such as dengue, Zika, and chikungunya1. Their ability to transmit pathogens is intrinsically linked to their hematophagous behavior, which presents metabolic challenges, particularly during blood digestion2,3. One major challenge is th...
ORGANISM(S): Serratia plymuthica 
2025-07-07 | PXD062643 | Pride
Heme detoxification Proteomics Oxidative stress Aedes aegypti Serratia plymuthica Midgut microbiota Hemin tolerance 
UnknownIdentification of essential histidine residues involved in heme binding and Hemozoin formation in heme detoxification protein from Plasmodium falciparum.
Not available
S-EPMC4138515 | biostudies-literature
UnknownHDP-a novel heme detoxification protein from the malaria parasite.
Not available
S-EPMC2291572 | biostudies-literature
UnknownMacrophage metabolic adaptation to heme detoxification involves CO-dependent activation of the pentose phosphate pathway.
Not available
S-EPMC7515686 | biostudies-literature
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