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TranscriptomicsCUT&RUN data of Chd4 and Mbd3 in mouse embryonic stem cells
This study investigates the role of ADNP in regulating CHD4 and MBD3 binding using CUT&RUN. CUT&RUN was performed to capture changes in the binding of CHD4 (using FLAG-tag) and MBD3. Two biological replicates were processed for each protein with two technical replicates. This dataset aims to charact...
ORGANISM(S): Mus musculus 
2026-01-15 | E-MTAB-15606 | biostudies-arrayexpress
TranscriptomicsRNA-seq data of mouse embryonic stem cells treated with auxin for CHD4 depletion against untreated control
This study investigates the role of the chromatin remodeller CHD4 in regulating gene expression. CHD4 was tagged with a mini-AID degron to enable auxin-inducible degradation. RNA-seq was performed at multiple time-points (1, 2, 4 and 24 hours) following auxin treatment to capture changes in gene exp...
ORGANISM(S): Mus musculus 
2026-01-15 | E-MTAB-15102 | biostudies-arrayexpress
TranscriptomicsNascent RNA-seq data of mouse embryonic stem cells treated with auxin for CHD4 depletion against untreated control
This study investigates the role of the chromatin remodeller CHD4 in regulating gene expression. CHD4 was tagged with a mini-AID degron to enable auxin-inducible degradation. RNA-seq of nascent transcripts was performed at multiple time-points (1, 2, 4 and 24 hours) following auxin treatment to capt...
ORGANISM(S): Mus musculus 
2026-01-15 | E-MTAB-15127 | biostudies-arrayexpress
TranscriptomicsATAC-seq data of mouse embryonic stem cells treated with dTAG for SALL4 depletion against untreated control
This study investigates the role of SALL4 in regulating chromatin accessibility. SALL4 was tagged with FKBP to enable dTAG-inducible degradation. ATAC-seq was performed at multiple time-points (1 hour, 4 hours and 8 hours) following dTAG treatment to capture changes in chromatin accessibility upon S...
ORGANISM(S): Mus musculus 
2026-01-15 | E-MTAB-15375 | biostudies-arrayexpress
TranscriptomicsRNA-seq of wild-type, Mbd3 and Sall4/1 mutant mouse embryonic stem cells
Mouse embryonic stem cells mutant for Mbd3, Sall4 and/or the related Sall1 pluripotency-associated factors were cultured in self-renewing and neural differentiation conditions and profiled by RNA-seq.
ORGANISM(S): Mus musculus 
2016-08-09 | E-MTAB-4566 | biostudies-arrayexpress
GenomicsChIP-seq of NuRD components and pluripotency factors in wild-type, Mbd3 and Sall4/1 mutant embryonic stem cells
Members of the Nucleosome Remodeling and Deacetylase (NuRD) complex Mbd3 and Mi2beta (Chd4) along with pluripotency regulators Nanog, Oct4, Klf4 and Esrrb were profiled for chromatin association by ChIP-seq in mouse embryonic stem cells mutant for Mbd3, Sall4 and/or the related Sall1 pluripotency-as...
ORGANISM(S): Mus musculus 
2016-08-09 | E-MTAB-4565 | biostudies-arrayexpress
TranscriptomicsControl of neural specification programmes by the NuRD complex
Apical progenitors from wild type and NestinCre:Mbd3Flox/Flox embryos at E12.5, E14.5 and E16.5 were used for gene expression microarray analyses to identify gene expression changes dependent upon a functional NuRD complex.
ORGANISM(S): Mus musculus 
2015-12-12 | E-MTAB-1332 | biostudies-arrayexpress
TranscriptomicsNuRD-mediated gene repression in mouse embryonic stem cells
To obtain a global view of NuRD-mediated transcriptional regulation, gene expression profiles of wild-type and Mbd3-null ES cells were compared by microarray analysis. In the absence of Mbd3, which encodes a core structural component of NuRD, the complex does not form and embryonic development stall...
ORGANISM(S): Mus musculus 
2012-03-13 | E-MTAB-889 | biostudies-arrayexpress
GenomicsNuRD-mediated gene repression in mouse embryonic stem cells
To obtain a global view of NuRD-mediated transcriptional regulation, gene expression profiles of wild-type and Mbd3-null ES cells were compared by microarray analysis. In the absence of Mbd3, which encodes a core structural component of NuRD, the complex does not form and embryonic development stall...
ORGANISM(S): Mus musculus 
2012-03-13 | E-MTAB-888 | biostudies-arrayexpress
TranscriptomicsChIP-chip of wild_type, K14MycER, K14Sin3afl/fl and K14Mycfl/fl in mouse whole genome Chr3
Identification of c-Myc, H3K4me3 and a set of skin differentiation specific TFs binding sites in the genome of normal or c-Myc overexpressed mouse epidermis
ORGANISM(S): Mus musculus 
2011-10-26 | E-MTAB-556 | biostudies-arrayexpress
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