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TranscriptomicsRNA-seq gene expression profiling of livers from wild-type male and female mice, and from mice with a Double Knockout (DKO) of Ezh1 and Ezh2.
PolyA-selected RNA isolated from livers of adult male and female mice with a combined loss of EZH1 and EZH2 in hepatocytes was analyzed by RNA-seq. The DKO mouse model used in these analyses is a global deletion of Ezh1 and hepatocyte-specific deletion of Ezh2, and is described in Bae WK, Kang K, Yu...
ORGANISM(S): Mus musculus 
2020-04-28 | GSE110879 | GEO
GenomicsGenome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes.
Signal Transducers and Activators of Transcription (STAT) 5A/B regulate cytokine-inducible genes upon binding to GAS motifs. It is not known what percentage of genes with GAS motifs bind to and are regulated by STAT5. Moreover, it is not clear whether genome-wide STAT5 binding is modulated by its co...
ORGANISM(S): Mus musculus 
2012-01-12 | E-GEOD-34986 | biostudies-arrayexpress
UnknownGenetic ablation of Bcl-x attenuates invasiveness without affecting apoptosis or tumor growth in a mouse model of pancreatic neuroendocrine cancer.
Not available
S-EPMC2635964 | biostudies-literature
GenomicsImpact of STAT5 dosage and binding location on genetic and biological programs activated in mouse mammary epithelium during pregnancy.
The transcription factor STAT5 has long been recognized as an important mediator of prolactin induced mammary development during pregnancy. We have used mouse genetics and genome-wide analyses to determine how altering concentrations of STAT5A and STAT5B impacts different target promoters. Examinati...
ORGANISM(S): Mus musculus 
2012-09-18 | E-GEOD-40930 | biostudies-arrayexpress
TranscriptomicsDistinct STAT5 concentrations uniquely control establishment and differentiation of mammary epithelium during pregnancy
To dissect regulatory processes of cell proliferation and differentiation we generated mouse strains carrying any combination of the four Stat5 alleles, thus expressing STAT5 from 0 to 100%. RNA-Seq analyses revealed that different STAT5 levels activate specific genetic programs linked to cell proli...
ORGANISM(S): Mus musculus 
2012-05-02 | E-GEOD-37646 | biostudies-arrayexpress
TranscriptomicsGenome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes
Stat5+/- mice were bred into the C57BL/6 background. Stat5+/- mice were intercrossed and mouse embryonic fibroblasts (MEFs) were isolated from 12.5-13.5-day WT or Stat5-/- fetuses. The retroviral-expression vector carrying a wild-type Stat5A gene based on an MSCV-IRES-GFP backbone (gift from Richard...
ORGANISM(S): Mus musculus 
2012-03-14 | E-GEOD-33688 | biostudies-arrayexpress
TranscriptomicsDevelopment of mammary luminal progenitor cells is controlled by the transcription factor STAT5A
Mammary alveologenesis is abrogated in the absence of the transcription factors STAT5A/5B that mediate cytokine signaling. To reveal the underlying causes for this developmental block we studied mammary stem and progenitor cells. While loss of STAT5A/5B did not affect the stem cell population and ...
ORGANISM(S): Mus musculus 
2009-10-21 | E-GEOD-17723 | biostudies-arrayexpress
TranscriptomicsThe gene encoding the hematopoietic stem cell regulator CCN3 (NOV) is under direct cytokine control through the transcription factors STAT5a/b.
Cytokines control the biology of hematopoietic stem and progenitor cells in part through the transcription factors STAT5a/b. CCN3/NOV has been reported as a positive regulator of hematopoietic stem and progenitor cells. We report microarray analyses of Lineage- Sca-1+ c-Kit+ (KSL) cells in the pre...
ORGANISM(S): Mus musculus 
2010-08-25 | E-GEOD-20684 | biostudies-arrayexpress
UnknownActivation of the SARS-CoV-2 Receptor Ace2 through JAK/STAT-Dependent Enhancers during Pregnancy.
Not available
S-EPMC7474886 | biostudies-literature
UnknownMMTV-Cre transgenes can adversely affect lactation: considerations for conditional gene deletion in mammary tissue.
Not available
S-EPMC3053441 | biostudies-literature
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