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ProteomicsSystematic Analysis of Plasma-Derived Extracellular Vesicle-Enriched Samples in Age-Related Macular Degeneration Reveals Oxidative Stress Linked to Altered Lipid and Protein Profiles
Vision impairment caused by age-related macular degeneration (AMD) is a global health priority. Retinal pathology is driven by aging and exacerbated by genetic and environmental risk factors. Peripheral blood circulation is increasingly recognised as a contributor to disease initiation and progressi...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD076119 | Pride
ProteomicsA microscopy-based screen identifies cellular kinases modulating mitochondrial translation
Mitochondrial DNA encodes thirteen subunits of the oxidative phosphorylation (OXPHOS) system, which are synthesized inside the organelle and essential for cellular energy supply. How mitochondrial gene expression is regulated and integrated into cellular physiology is little understood. Here, we per...
ORGANISM(S): Homo sapiens (Human) 
2025-01-02 | PXD053045 | Pride
Mitochondrial translation Dia Immunoisolation Cellular kinases Sirna library Click chemistry 
ProteomicsCell-autonomous restoration of splicing homeostasis and RP11 phenotype in patient-derived RPE and retinal organoids by PRPF31.AAV gene therapy
Mutations in PRPF31 cause Retinitis pigmentosa type 11 (RP11) through haploinsufficiency, impairing spliceosome assembly and triggering progressive retinal degeneration. While gene augmentation holds therapeutic promise, key questions remain regarding the mechanistic basis of rescue and its therapeu...
ORGANISM(S): Homo sapiens (Human) 
2026-09-30 | PXD076430 | Pride
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