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ProteomicsThe dual life of disordered lysine-rich domains of snoRNPs in rRNA modification and nucleolar compaction
Intrinsically disordered regions (IDRs) are highly enriched in the nucleolar proteome but their physiological role in ribosome assembly remains poorly understood. Our study reveals the functional plasticity of the extremely abundant lysine-rich IDRs of small nucleolar ribonucleoprotein particles (sn...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-10-18 | PXD056946 | Pride
Snornp Lysine-rich idr Saccharomyces cerevisiae 
UnknownThe Terminal Extensions of Dbp7 Influence Growth and 60S Ribosomal Subunit Biogenesis in Saccharomyces cerevisiae.
Not available
S-EPMC9960301 | biostudies-literature
ProteomicsNucleotide independant as well as ATP-hydrolysis driven steps of Rea1 Linker remodelling drive the removal of assembly factors from pre-ribosomal particles: PhoX cross-linking of Rea1 in presence of ATPgS, AMP-PNP or Apo state.
The ribosome maturation factor Rea1 (or Midasin) catalyses the removal of assembly factors from large ribosomal subunit precursors and to promotes their export from the nucleus to the cytosol. Rea1 consists of nearly 5000 amino-acid residues and belongs to the AAA+ protein family. It consists of a r...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-07-29 | PXD053636 | Pride
Cross-linking mass spectrometry Structural biology Structural proteomics 
UnknownThe snoRNP chaperone snR190 and the Npa1 complex form a macromolecular assembly required for 60S ribosomal subunit maturation.
Not available
S-EPMC11879421 | biostudies-literature
UnknownRemodelling of Rea1 linker domain drives the removal of assembly factors from pre-ribosomal particles.
Not available
S-EPMC11603028 | biostudies-literature
UnknownThe dual life of disordered lysine-rich domains of snoRNPs in rRNA modification and nucleolar compaction.
Not available
S-EPMC11528048 | biostudies-literature
UnknownAssociation of snR190 snoRNA chaperone with early pre-60S particles is regulated by the RNA helicase Dbp7 in yeast.
Not available
S-EPMC8536666 | biostudies-literature
TranscriptomicsTranscription profiling of human childhood B-lineage ALL patients reveals five distinct biological processes and 14 differentially expressed genes characterize TEL/AML1-positive leukemia
Background; The t(12;21)(p13;q22) translocation is found in 20 to 25% of cases of childhood B-lineage acute lymphoblastic leukemia (B-ALL). This rearrangement results in the fusion of ETV6 (TEL) and RUNX1 (AML1) genes and defines a relatively uniform category, although only some patients suffer very...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9170 | biostudies-arrayexpress
UnknownOverall Survival Among Patients With Hepatocellular Carcinoma Treated With External Beam Radiation Therapy: Individual Patient Data Outcomes From a Multinational Cohort.
Not available
S-EPMC13313461 | biostudies-literature
UnknownIncidence and predictors of post-thrombotic syndrome in patients with proximal DVT in a real-world setting: findings from the GARFIELD-VTE registry.
Not available
S-EPMC10869374 | biostudies-literature
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