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described in: Pharmacokinetic-pharmacodynamic modeling of caffeine: Tolerance to pressor effects Shi J, Benowitz NL, Denaro CP and Sheiner LB. ;Clin. Pharmacol. Ther. 1993 Jan;53(1):6-14. PMID:8422743; Abstract: We propose a parametric pharmacokinetic...
2024-09-02 | BIOMD0000000241 | BioModels
MAM (Microbial-Anti-Inflammatory Molecule) is a 14,5 kDa protein that is one of the best-known effector molecules with anti-inflammatory properties in Faecalibacterium duncaniae, a critical species in the human gut microbiota. Despite its importance, MAM function and molecular features remain poorly...
ORGANISM(S): Faecalibacterium prausnitzii A2-165 
2025-06-30 | PXD057939 | Pride
Major depressive disorder (MDD) is the psychiatric disorder with the highest prevalence in the world. Pharmacological antidepressant treatment (AD), such as selective serotonin reuptake inhibitors [SSRI, i.e. fluoxetine (Flx)] is the first line of treatment for MDD. Despite its efficacy, lack of AD ...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-01 | PXD037392 | Pride
Immune checkpoint blockade (ICB) leads to durable and complete tumour regression in some patients but in others gives temporary, partial or no response. Accordingly, significant efforts are underway to identify tumour-intrinsic mechanisms underlying ICB resistance. Results from a published CRISPR sc...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-18 | PXD035392 | Pride
This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model ha...
2005-01-01 | MODEL1101100000 | BioModels
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