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TranscriptomicsAdvanced Age is Associated with Worsened Outcomes and a Unique Genomic Response in Severely Injured Patients with Hemorrhagic Shock
We performed epidemiological, cytokine, and transcriptomic analyses on a prospective, multi-center cohort of 1,928 severely injured patients. We wished to characterize the relationship of advanced age to clinical outcomes and to transcriptomic responses after severe blunt traumatic injury with hemor...
ORGANISM(S): Homo sapiens 
2015-01-06 | E-GEOD-64711 | biostudies-arrayexpress
TranscriptomicsA genomic storm in critically injured humans
Human survival from injury requires an appropriate inflammatory and immune response. We describe the circulating leukocyte transcriptome after severe trauma and show that the severe stress produce a global reprioritization affecting >80% of the cellular functions and pathways, a truly unexpected “ge...
ORGANISM(S): Homo sapiens 
2012-03-26 | E-GEOD-36809 | biostudies-arrayexpress
TranscriptomicsGene response to major burn injuries
Blood was sampled from severe burns patients over time as well as healthy subjects. Genome-wide expression analyses were conducted using the Affymetrix U133 plus 2.0 GeneChip™. The Inflammation and the Host Response to Injury Large-Scale Collaborative Research Program Blood was sampled from 244 seve...
ORGANISM(S): Homo sapiens 
2013-02-12 | E-GEOD-37069 | biostudies-arrayexpress
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