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TranscriptomicsTargeting the EWS/ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma
Ewing sarcomas (ES) are highly malignant, osteolytic bone or soft tissue tumors, which are characterized by early metastasis into lung and bone. Genetically, ES are defined by balanced chromosomal EWS/ETS translocations, which give rise to chimeric proteins (EWS-ETS) that generate an oncogenic trans...
ORGANISM(S): Homo sapiens 
2015-12-08 | E-GEOD-72673 | biostudies-arrayexpress
GenomicsLoss of EZH2 results in enhanced recruitment of EZH1, Pol II and Stat5 and precocious mammary gland development
Establishment and differentiation of mammary alveoli during pregnancy are controlled by prolactin through the transcription factor STAT5. As pregnancy progresses mammary signature genes are activated in a defined temporal order, which coincides with the recruitment of STAT5 to respective regulatory ...
ORGANISM(S): Mus musculus 
2015-01-27 | E-GEOD-65284 | biostudies-arrayexpress
TranscriptomicsLoss of EZH2 results in precocious mammary gland development and the activation of STAT5-dependent genes
Establishment and differentiation of mammary alveoli during pregnancy are controlled by prolactin through the transcription factor STAT5. As pregnancy progresses mammary signature genes are activated in a defined temporal order, which coincides with the recruitment of STAT5 to respective regulatory ...
ORGANISM(S): Mus musculus 
2015-08-31 | E-GEOD-70440 | biostudies-arrayexpress
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