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TranscriptomicsDot1 and Histone H3K79 Methylation in Natural Heterochromatic and HML/HMR Silencing
Dot1 is a methyl transferase that has been shown through a reporter gene to be involved in position effect variegation of gene expression in heterochrmatic regions such as telomeres and the mating type loci in yeast. This study examines the effect of mutation of DOT1 and two other proteins involved ...
ORGANISM(S): Saccharomyces cerevisiae 
2011-02-12 | E-GEOD-27234 | biostudies-arrayexpress
TranscriptomicsGene deletion expression profiles of yeast chromatin modifiers
Packaging of DNA into chromatin has a profound impact on gene expression. To understand how changes in chromatin influence transcription, we analyzed 165 mutants of chromatin machinery components in Saccharomyces cerevisiae. mRNA expression patterns change in 80% of mutants, always with specific eff...
ORGANISM(S): Saccharomyces cerevisiae 
2011-05-23 | E-GEOD-25909 | biostudies-arrayexpress
UnknownClinical, genetic, epidemiologic, evolutionary, and functional delineation of TSPEAR-related autosomal recessive ectodermal dysplasia 14.
Not available
S-EPMC10064225 | biostudies-literature
UnknownMutations in the Key Autophagy Tethering Factor EPG5 Link Neurodevelopmental and Neurodegenerative Disorders Including Early-Onset Parkinsonism.
Not available
S-EPMC12577676 | biostudies-literature
UnknownAn interconnected data infrastructure to support large-scale rare disease research.
Not available
S-EPMC11413801 | biostudies-literature
UnknownClonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy.
Not available
S-EPMC4472749 | biostudies-literature
UnknownOlder patients with chronic myeloid leukemia (≥65 years) profit more from higher imatinib doses than younger patients: a subanalysis of the randomized CML-Study IV.
Not available
S-EPMC4050299 | biostudies-literature
UnknownComprehensive reanalysis for CNVs in ES data from unsolved rare disease cases results in new diagnoses.
Not available
S-EPMC11513043 | biostudies-literature
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