Gene deletion expression profiles of yeast chromatin modifiers

ABSTRACT: Packaging of DNA into chromatin has a profound impact on gene expression. To understand how changes in chromatin influence transcription, we analyzed 165 mutants of chromatin machinery components in Saccharomyces cerevisiae. mRNA expression patterns change in 80% of mutants, always with specific effects, even for loss of widespread histone marks. This results in the first network of chromatin interaction pathways. The network is function-based, has a branched, interconnected topology and lacks strict one-to-one relationships between complexes. Chromatin pathways are not separate entities for different gene sets, but share many components. The study evaluates which interactions are rate-limiting for which genes and predicts new interactions, for example between Paf1C and Set3C, as well as a

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Patrick Kemmeren 

PROVIDER: E-GEOD-25909 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress