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MetabolomicsWashed Microbiota Transplantation for Overt Hepatic Encephalopathy: A Feasibility Pilot Study
Objective:Washed microbiota transplantation may modulate the gut-liver-brain axis in hepatic encephalopathy (HE). Evidence in overt HE (OHE) remains limited, and previous trials have enrolled patients in remission rather than during an active episode. Methods:In this prospective, non-randomized pilo...
2026-07-21 | MTBLS15106 | MetaboLights
ProteomicsProteomic analysis of hippocampal proteins in moderate hepatic encephalopathy rat model
Hepatic Encephalopathy is the brain disorder caused by liver damage, characterized by cognitive and motor impairments. Glutamate a predominant excitatory neurotransmitter over activate post-synaptic neuron via NMDAR receptors leads to neuronal derangement. NMDAR as a therapeutic target is not viabl...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-05-27 | PXD036723 | Pride
Hippocampus Rat Hepatic encephalopathy Lc-ms/ms Label free 
TranscriptomicsGene expression profiling in post mortem brain samples of patients with cirrhosis with and without hepatic encephalopathy
The study aimed at the identification of gene expression changes in brain of cirrhotic patients without or with HE as compared to controls. Tissue was taken from the fusiform gyrus. The dataset comprises 12 brain tissue samples divided into three sample groups each representing a certain liver dise...
ORGANISM(S): Homo sapiens 
2014-10-23 | E-GEOD-57193 | biostudies-arrayexpress
GenomicsGut microbiota dysbiosis in Cirrhosis and hepatic encephalopathy
Gut microbiota dysbiosis in Cirrhosis and hepatic encephalopathy
PRJEB65440 | ENA
TranscriptomicsGene expression of rat cerebellum in a new animal model of hepatic encephalopathy (HE)
Identify differentially expressed genes related to the neurodegenerative process in a new animal model of hepatic encephalopathy (HE). The animal model consists on the simulation of several bouts of HE in PCA rats, being the precipitant factors of the episodes ammonia (NH3) and/or lipopolisaccharide...
ORGANISM(S): Rattus norvegicus 
2015-07-29 | E-GEOD-71425 | biostudies-arrayexpress
ProteomicsProteomic analysis of cerebellum of hepatic encephalopathy rat model
Hepatic Encephalopathy is the brain disorder caused by liver damage, characterized by cognitive and motor impairments. Glutamate a predominant excitatory neurotransmitter over activate post-synaptic neuron via NMDAR receptors leads to neuronal derangement. NMDAR as a therapeutic target is not viabl...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-04-29 | PXD036573 | Pride
TranscriptomicsWhite Matter transcriptome in chronic alcoholism
Chronic alcohol consumption can lead to alchohol-related brain damage (ARBD). Despite the well known acute effects of alcohol the mechanism responsible for chronic brain damage is largely unknown. Pathologically the major change is the loss of white matter while neuronal loss is mild and restricted ...
ORGANISM(S): Homo sapiens 
2014-01-04 | E-GEOD-53808 | biostudies-arrayexpress
GenomicsExperimental hepatic encephalopathy causes early but sustained glial transcriptional changes
Experimental hepatic encephalopathy causes early but sustained glial transcriptional changes
PRJNA958186 | ENA
TranscriptomicsGene expression profiling in the cerebral cortex of patients with cirrhosis with and without hepatic encephalopathy
Hepatic encephalopathy (HE) is a frequent complication of liver cirrhosis and is seen as the clinical manifestation of a low grade cerebral edema associated with oxidative-nitrosative stress, however, comprehensive data on HE-associated molecular derangements in human brain are lacking. In the prese...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-41919 | biostudies-arrayexpress
Genomics
Hepatic encephalopathy mice
PRJNA1088623 | ENA
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