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MetabolomicsHepatocyte Differentiation Metabolism
Not available
ORGANISM(S): Homo sapiens 
ST000837 | MetabolomicsWorkbench
TranscriptomicsGene expression profile of human embryonic stem cell-derived hepatocyte-like cells
The differentiation of pluripotent stem cells to hepatocyte-like cells offers the perspective of unlimited supply of human hepatocytes. However, the degree of differentiation of hepatic-like cells (HLC) remains controversial. To obtain an unbiased characterization, we performed a transcriptomics st...
ORGANISM(S): Homo sapiens 
2016-02-24 | E-MTAB-4442 | biostudies-arrayexpress
TranscriptomicsDifferentiation of human embryonic stem cells towards hepatocytes
To understand in detail the molecular phases that occur during the differentiation of human embryonic stem cells to hepatocyte-like cells we performed an RNA-seq time course of the stages of differentiation across the 21 day differentiation time course. We used a chemically defined (serum-free) prot...
ORGANISM(S): Homo sapiens 
2017-04-28 | E-GEOD-70741 | biostudies-arrayexpress
ProteomicsTranscriptomic and Proteomic Response of HC-04 to hepatocyte growth factor (HGF)
The routine study of human malaria liver-stage biology in vitro is hampered by low infection efficiency of human hepatocellular carcinoma (HCC) lines (<0.1%), poor understanding of steady-state HCC biology, and lack of appropriate tools for trace sample analysis. HC-04 is the only HCC that supports ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-20 | MSV000079959 | MassIVE
MetabolomicsMetabolomics profiling (GC-MS and LC-MS) for time-course differentiation of pre-B cells-like (B3 cell line) under the controlled induction of the transcription factor Ikaros (STATegra Project)
The main goal of the project is to develop a new generation of bioinformatics resources for the integrative analysis of multiple types of 'omics data. These resources include both novel statistical methodologies as well as user-friendly software implementations. STATegra methods address many aspects...
2016-12-15 | MTBLS283 | MetaboLights
TranscriptomicsHuman embryonic stem cells as a tool to study hepatocyte differentiation
The availability of pluripotent stem cells offers the possibility of using such cells to model hepatic disease and development. With this in mind, we previously established a protocol that facilitates the differentiation of both human embryonic stem cells and induced pluritpotent cells into cells wi...
ORGANISM(S): Homo sapiens 
2011-08-21 | E-GEOD-25417 | biostudies-arrayexpress
GenomicsCDK5RAP3 regulates hepatocyte differentiation in human
CDK5RAP3 regulates hepatocyte differentiation in human
PRJNA1064096 | ENA
TranscriptomicsGene expression profile of human embryonic stem cell-derived hepatocyte-like cells in matrigel and recombinant laminins
Stem cell derived somatic cells represent an unlimited resource for basic and translational science. While promising, there are significant hurdles that must be overcome. Our focus is on the generation of the major cell type of the human liver, the hepatocyte. Current protocols produce variable pop...
ORGANISM(S): Homo sapiens 
2016-01-18 | E-MTAB-3994 | biostudies-arrayexpress
ProteomicsConditions for maintenance of hepatocyte differentiation and function in 3D cultures
3D spheroid cultures of primary human hepatocytes (PHH) are used in studies of hepatic drug metabolism and toxicity. However, the 3D spheroids are maintained under different conditions, with possible cofounding results. Here we performed an in-depth analysis of how various culture conditions influen...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD024632 | Pride
Primary human hepatocyte culture Lc-ms/ms 
UnknownComparison of commercially available media for hepatic differentiation and hepatocyte maintenance.
Not available
S-EPMC7046223 | biostudies-literature
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