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ProteomicsDomain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities
Mis-sense mutations affecting TP53 promote carcinogenesis both by inactivating its tumor suppressive functions, and by conferring aberrant pro-carcinogenic activities. We report here that mis-sense mutants in the p53 DNA-binding domain (DBD) and the transactivation domain (TAD) unexpectedly activate...
ORGANISM(S): Homo Sapiens (human) 
2023-02-17 | PXD031725 | JPOST Repository
UnknownMedicaid Expansion Increased Preconception Health Counseling, Folic Acid Intake, And Postpartum Contraception.
Not available
S-EPMC7688246 | biostudies-literature
TranscriptomicsBidirectional manipulation of SF-1 (NR5A1) in NCI-H295R cells
SF-1 (NR5A1) was overexpressed (Over) or knocked down with shRNA (shRNA) in NCI-H295R human adrenocortical tumor cells and differential global gene expression analysed 48 hours later using Affymetrix GeneChip Human Gene 1.0ST arrays. Over: 5 million cells were transfected (Amaxa Nucleofection) with ...
ORGANISM(S): Homo sapiens 
2011-01-11 | E-GEOD-26529 | biostudies-arrayexpress
TranscriptomicsIdentification of the miRNA targetome in hippocampal neurons using RIP-seq
We established a neuron-specific Argonaute2:GFP-RNA immunoprecipitation followed by high throughput sequencing (AGO2-RIP-seq) to analyse the regulatory role of miRNAs in mouse hippocampal neurons. Using this technique, we identified more than two thousand miRNA target genes in hippocampal neurons, r...
ORGANISM(S): Mus musculus 
2015-07-31 | E-GEOD-65543 | biostudies-arrayexpress
TranscriptomicsExamination of DPY-30, DPY-27, SDC-3, DPY-26, MIX-1, SMC-4, ASH-2, RNA Polymerase II binding in wild type and DCC mutant embryos
Here we exploit the essential process of X-chromosome dosage compensation to elucidate basic mechanisms that control the assembly, genome-wide binding, and function of gene regulatory complexes that act over large chromosomal territories. We demonstrate that a subunit of C. elegans MLL/COMPASS, a g...
ORGANISM(S): Caenorhabditis elegans 
2011-03-01 | E-GEOD-25833 | biostudies-arrayexpress
TranscriptomicsGrowth responses and global gene expression analysis of transgenic mannitol-producing Arabidopsis thaliana
Mannitol is a sugar alcohol that serves as a compatible solute contributing to exceptional salt tolerance in several plant species. Arabidopsis plants transformed with the mannose-6-phosphate reductase (M6PR) gene from celery were dramatically more salt tolerant. Following treatment with 100mM NaCl,...
ORGANISM(S): Arabidopsis thaliana 
2010-03-07 | E-GEOD-18217 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Gene Expression Profiles in the Pancreatic Lymph Nodes of At-Risk Autoantibody Positive Individuals
Type 1 diabetes (T1D) is a polygenic autoimmune disorder caused by autoreactive T cells that recognize pancreatic islet antigens and subsequently destroy insulin-producing β-cells. Pancreatic lymph nodes (PLN) are an essential site for the development of T1D, where tolerance to pancreatic self-antig...
ORGANISM(S): Homo sapiens 
2015-03-03 | E-GEOD-66413 | biostudies-arrayexpress
TranscriptomicsNCIC CTG MA.22 phase I/II trial of epirubicin and docetaxel in locally advanced breast cancer on 2-weekly or 3-weekly schedules
This phase I/II neoadjuvant trial determined maximally-tolerated doses (MTD), dose-limiting toxicities (DLT), response-to-therapy, and explored the role of new response biomarkers. The combination regimens were delivered with acceptable toxicity, good clinical response, inducing changes in tumor RNA...
ORGANISM(S): Homo sapiens 
2015-11-11 | E-GEOD-66999 | biostudies-arrayexpress
TranscriptomicsTranscriptomics evaluation of hexavalent chromium toxicity in human dermal fibroblasts
Significant occupational and environmental exposures to hexavalent chromium, a metal with broad toxicity potential in humans, have been reported. In order to understand the mechanisms of dermal toxicity induced by hexavalent chromium, global gene expression profiling of human dermal fibroblasts expo...
ORGANISM(S): Homo sapiens 
2011-07-30 | E-GEOD-16349 | biostudies-arrayexpress
TranscriptomicsFed L1 larvae total RNA levels by microarray
Here we exploit the essential process of XM-bM-^@M-^Pchromosome dosage compensation to elucidate basic mechanisms that control the assembly, genomeM-bM-^@M-^Pwide binding, and function of gene regulatory complexes that act over large chromosomal territories. We demonstrate that a subunit of C. ele...
ORGANISM(S): Caenorhabditis elegans 
2011-03-01 | E-GEOD-25831 | biostudies-arrayexpress
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